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Achievements

May 10, 2013: MALDI Matrix List uploaded (additional materials)

　To date, Koichi Tanaka Lab. Adv. Sci.&Tech.(KTLAST) has uploaded several “useful materials” as reference materials for researchers including “MALDI-MS Technical Reports”.
　MALDI can analyze a wide range of compounds including amino acids/peptides/proteins, monosaccharides/sugar chains, conjugated lipids, nucleic acid-related compounds, metabolites, synthetic polymers, etc. However, selecting the appropriate ionization agent -the matrix- for each target compound is essential.
　Over the past 30 years, several hundred matrix candidates have been investigated and developed. The “MALDI Matrix List” is a 4-page compilation of 23 selected matrices including the most recently developed matrices at KTLAST.

　- MALDI Matrix List（1.19MB）

Nov. 11, 2010: Useful materials for researchers (additional materials)

　On October 18, information was uploaded related to 20 amino acids, which mainly make up proteins. The monosaccharide list was updated to include many monosaccharides which were recently discovered to be related to disease.

　- Monosaccharide List for Mass Spectrometer（322KB）

　For 20 monosaccharides important to humans and related to disease, chemical formulas, structural information, and chemical symbols are listed to assist with mass spectrometry analysis.

Oct. 18, 2010: Useful materials for researchers (additional materials)

　On October 1, MALDI-MS Technical Reports (Rev. 3.0) were uploaded to assist MALDI-MS researchers and engineers. This time, useful information has been uploaded for bio-chemical and molecular biology researchers.

  • Amino Acid Table（150KB）
    Structural information and physical/chemical features of 20 amino acids that compose proteins, listed in an easy-to-use reference chart format.
  • Mutation Mass Shifts（227KB）
    Mass differences when mutations occurred in gene information were compared to codon information and shown in a reference chart for 20 amino acids that compose proteins. Divided into Part 1/2 Nominal Mass (simple) and Part 2/2 Monoisotopic Mass (more precise).

Oct. 1, 2010: MALDI-MS Technical Reports uploaded.

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- No.03 Why Is MS/MS Analysis Possible in Reflectron Mode?（383KB）

(Reference: Why Can Reflectron Mode in Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Perform MS/MS-like Analysis?, J. Mass Spectrom. Soc. Jpn., )

- No.04 What Can We Find Out in Neutral Detection Mode?（266KB）

- No.05 What Is an Appropriate Detector for MALDI-TOFMS?（321KB）

(Reference: Detectors for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer, J. Mass Spectrom. Soc. Jpn., )

- No.06 What Is an Inorganic Matrix? What Are Its Characteristics?（437KB）

- No.07 What Are the Differences Between MALDI and LI/LD?（298KB）

- No.08 What Is the MALDI Matrix Invented by Shimadzu?（772KB）

- No.09 What Is a Quadrupole Ion Trap? What Are Its Characteristics?（621KB）

- No.10 What Are the Best Measurement Circuits for TOF-MS?（848KB）

- Back Cover Mass Spectrometry as an Academic Discipline（252KB）

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- All pages（5,247KB）

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　The Shimadzu Koichi Tanaka Mass Spectrometry Research Laboratory has been periodically publishing MALDI-MS Technical Reports to help researchers better understand MALDI-MS. In many research labs where mass spectrometers are used, these reports are used as textbooks to understand basics and develop applications for mass spectrometers. The Mass Spectrometry Society of Japan edited four of the chapters and posted them in the society’s journal.

　A Rev. 3.0 of these reports has been prepared. To make them available to as many researchers as possible, they have been posted on this website as PDF files. They are available for download at your convenience.

＜MALDI-MS Technical Reports (Rev.3.0)＞

- Cover（358KB）

- No.01 Why Does Mass Resolution Improve in Reflectron Mode?（570KB）

(Reference: Why Can Reflectron and Multi-Turn Time-of-Flight Mass Spectrometer Improve Their Mass Resolving Powers?, J. Mass Spectrom. Soc. Jpn.,

- No.02 What Is the Pulsed Extraction Technique?（382KB）

(Reference: Principles of Delayed Extraction Technique, J. Mass Spectrom. Soc. Jpn., )

- No.03 Why Is MS/MS Analysis Possible in Reflectron Mode?（383KB）

(Reference: Why Can Reflectron Mode in Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Perform MS/MS-like Analysis?, J. Mass Spectrom. Soc. Jpn., )

- No.04 What Can We Find Out in Neutral Detection Mode?（266KB）

- No.05 What Is an Appropriate Detector for MALDI-TOFMS?（321KB）

(Reference: Detectors for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer, J. Mass Spectrom. Soc. Jpn., )

- No.06 What Is an Inorganic Matrix? What Are Its Characteristics?（437KB）

- No.07 What Are the Differences Between MALDI and LI/LD?（298KB）

- No.08 What Is the MALDI Matrix Invented by Shimadzu?（772KB）

- No.09 What Is a Quadrupole Ion Trap? What Are Its Characteristics?（621KB）

- No.10 What Are the Best Measurement Circuits for TOF-MS?（848KB）

- Back Cover Mass Spectrometry as an Academic Discipline（252KB）

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- All pages（5,247KB）

2011 Research Achievements

1. Journal Papers (4) (refereed: 4)

  1. Kaoru Kaneshiro, Yuko Fukuyama, Shinichi Iwamoto, Sadanori Sekiya, and Koichi Tanaka
    　Koichi Tanaka Mass Spectrometry Research Laboratory and Koichi Tanaka Laboratory of Advanced Science and Technology*)
    “Highly Sensitive MALDI Analyses of Glycans by a New Aminoquinoline-Labeling Method Using 3-Aminoquinoline/α-Cyano-4-hydroxycinnamic Acid Liquid Matrix”
    Analytical Chemistry., 2011, Vol. 83 No.10, pp3663-3667
    Presentation materials
    *）Affiliated with both organizations, as the Koichi Tanaka Laboratory of Advanced Science and Technology took over research from the Koichi Tanaka Mass Spectrometry Research Laboratory.
  2. Takashi Shimada1,2, Atsuhiko Toyama1, Chikage Aoki1, Yutaka Aoki1, Koichi Tanaka2,3, Taka-Aki Sato1,2
    “Direct antigen detection from immunoprecipitated beads using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; a new method for immunobeads-mass spectrometry (iMS)”, Rapid Commun. Mass Spectrom. 2011, 25, pp3521-3526
    1 Life Science Research Center, Shimadzu Corporation
    2 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    3 Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation
  3. Daniel J. CAPON1, Naoki KANEKO2, Takayuki YOSHIMORI2, Takashi SHIMADA2, Florian M. WURM3, Peter K. HWANG4, Xiaohe TONG5, Staci A. ADAMS1, Graham SIMMONS1, Taka-Aki SATO2 and Koichi TANAKA2
    “Flexible antibodies with nonprotein hinges”, Proceedings of the Japan Academy, Series B, Vol. 87 pp603-616 (2011)
    1 Blood Systems Research Institute, San Francisco, U.S.A.
    2 Koichi Tanaka Laboratory of Advanced Science and Technology, Kyoto, Japan.
    3 Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
    4 University of California, San Francisco, California, U.S.A.
    5 CPC Scientific, Sunnyvale, California, U.S.A.
  4. Takashi Shimada1,2, Hiroki Kuyama1, Taka-Aki Sato1,2, Koichi Tanaka1
    “Development of iodoacetic acid-based cysteine mass tags: Detection enhancement for cysteine-containing peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry”, Analytical Biochemistry, 2012, Issue 2, pp785-787
    1 SHIMADZU Corporation, Koichi Tanaka Laboratory of Advanced Science and Technology
    2 SHIMADZU Corporation, Life Science Research Center

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2. Presentations (20) (Invited: 0)

  1. [ThP583] Yuko Fukuyama1, Natsumi Funakoshi1, Shinichi Iwamoto1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    Highly sensitive MALDI analyses of glycopeptides using liquid matrices 3-AQ/CHCA and 3-AQ/CA, 59th ASMS Conference on Mass Spectrometry and Allied Topics, June 5 – 9, 2011
    →　Describes the highly sensitive analysis of glycopeptides to 10 amol max. (100 times greater than before) using the newly developed liquid matrix 3-AQ/CHCA.
    Presentation materials（383KB）
  2. [MP445] Kentaro Morimoto1, Masaki Murase1, Tsuyoshi Tabata2, Shigeki Kajihara1, Yoshiya Oda2, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd.
    Peptide search algorithm by selecting and rescoring reliable peaks for MSn(n>1) spectra, 59th ASMS Conference on Mass Spectrometry and Allied Topics, June 5 – 9, 2011
    →　Normally, only MS/MS data is referenced to obtain peptide sequence information. However, this presentation illustrates that the identification rate can be enhanced by combining MS3 and higher information and introduces the associated algorithms.
    Presentation materials（287KB）
  3. [ThP383] Satoshi Tanaka1, Shigeki Kajihara1, Shinichi Utsunomiya1, Tsuyoshi Tabata2, Ken Aoshima2, Yoshiya Oda2, Yoshito Nihei3, Takaaki Nishioka3 , Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd., 3 BIRD, JST, Keio University
    Development of a client tool for a mass spectra database, 59th ASMS Conference on Mass Spectrometry and Allied Topics, June 5 – 9, 2011
    →　Mass++ is free software for viewing and analysis in mass spectrometry. Plug-in software was developed to connect Mass++ with the MassBank free database, simplifying the searching of large data sets.
    Presentation materials（1,631KB）
  4. [1P-09] Yusaku Hioki1, Yuko Fukuyama1, Chikako Hamana1, Shinichi Iwamoto1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Improving the Sensitivity in MALDI-MS Analyses by Using Deposition of Small Droplet”, The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  5. [1P-12] Kaoru Kaneshiro1, Makoto Watanabe1, Kazuya Terasawa2, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 World-Leading Drug Discovery Research Center, Faculty of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University
    “N-Glycan profiling of HER2 by AQlabeling method with 3-AQ/CHCA liquid matrix,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  6. [1P-40] Yuko Fukuyama1, Natsumi Funakoshi1, Shinichi Iwamoto1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Highly sensitive MALDI analyses of glycopeptides using liquid matrices 3-AQ/CHCA and 3-AQ/CA,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  7. [1P-49] Kei Kodera1, Masafumi Jinno1, Kiyoshi Watanabe1, Makoto Hazama1, Masaji Furuta1, Sadanori Sekiya1, Kaori Kinoshita1, Hidenori Takahashi1, Kosuke Hosoi1, Toshinori Kobayashi1, Shinichi Iwamoto1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “MALDI-Digital-Ion-Trap-TOFMS with Ion Trap Pass-through TOF Mode,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  8. [2P-01] Howell Parry1, Satoshi Tanaka1, Tsuyoshi Tabata2, Ken Aoshima2, Yoshiya Oda2, Yoshito Nihei3, Takaaki Nishioka3, Shinichi Utsunomiya1, Shigeki Kajihara11 Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd., 3 Nara Institute of Science and Technology
    “Mass++ 2.0.0: New version of freeware mass spectrometry analysis software,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  9. [2P-11] Kenichi Taniguchi1, Yuko Fukuyama1, Yutaka Ibuki1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Highly sensitive analysis of glycopeptides using labeling technique by MALDI-MS,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  10. [2P-24] Takashi Shimada1, Taka-Aki Sato1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Development of novel MS probes for high-sensitivity proteomics,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  11. [2P-40] Yuko Fukuyama1, Ritsuko Tanimura1, Shunsuke Izumi2, Shinichi Iwamoto1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Graduate School of Science, Hiroshima University
    “Highly sensitive MALDI analyses of hydrophobic peptides using a novel additive ADHB with conventional matrices,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  12. [3P-01] Kentaro Morimoto1, Masaki Murase1, Tsuyoshi Tabata2, Shigeki Kajihara1, Ken Aoshima2, Yoshiya Oda2, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd.
    “Evaluation of a novel database search algorithm using MSn spectra,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  13. [3P-21] Akiyasu Yoshizawa1, Tsuyoshi Tabata2, Takayuki Kimura2, Ken Aoshima2, Yoshiya Oda2, Shigeki Kajihara1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd.
    “Application of post-translational modification information in database search,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  14. [3P-26] Kazuya Terasawa1, Hiromasa Uchimura1, Kaoru Kaneshiro2, Makoto Watanabe2, Kazuharu Shimizu1, Gozoh Tsujimoto1, Koichi Tanaka2
    　1 World-Leading Drug Discovery Research Center, Faculty of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, 2 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Estimation of HER2 N-glycosylation ratio using MALDI MS,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  15. [3P-40] Yuko Fukuyama1, Kohei Takeyama1, Shinichi Iwamoto1, Koichi Tanaka1
    　1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Highly sensitive MALDI analyses of phosphorylated peptides using an optimized liquid matrix 3-AQ/CHCA,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  16. [2P-0344] Akiyasu Yoshizawa1, Tsuyoshi Tabata2, Takayuki Kimura2, Ken Aoshima2, Yoshiya Oda2, Shigeki Kajihara1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 EPCS, Eisai Co., Ltd.
    “Application of post-translational modification information in MS database search,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  17. [2P-0395] Kaoru Kaneshiro1, Makoto Watanabe1, Yuko Fukuyama1, Kazuya Terasawa2, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Taka-Aki Sato1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 Graduate School of Pharmaceutical Sciences, Kyoto University
    “N-glycan profiling of HER2 by AQ-labeling method with 3-AQ/CHCA liquid matrix,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  18. [2P-0396] Kazuya Terasawa1, Hiromasa Uchimura1, Kaoru Kaneshiro2, Makoto Watanabe2, Yuko Fukuyama2, Kazuharu Shimizu1, Gozoh Tsujimoto1, Taka-Aki Sato2, Koichi Tanaka2
    1 Graduate School of Pharmaceutical Sciences, Kyoto University
    2 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    “Estimation of HER2 N-glycosylation ratio using MALDI MS,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  19. [2P-0397] Makoto Watanabe1, Kazuya Terasawa2, Kaoru Kaneshiro1, Yuko Fukuyama1, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Taka-Aki Sato1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 Graduate School of Pharmaceutical Sciences, Kyoto University
    “Phosphorylated peptide analysis of HER2 using a liquid matrix 3-AQ/CHCA,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  20. [4P-0634] Yuko Fukuyama1, Kaoru Kaneshiro1, Makoto Watanabe1, Kazuya Terasawa2, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Taka-Aki Sato1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 Graduate School of Pharmaceutical Sciences, Kyoto University
    “Phosphorylated peptide analysis of HER2 using a liquid matrix 3-AQ/CHCA,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011

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3. Published Books (0)

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4. Industrial Property Rights Applications (pending but unregistered only) (24)

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5. Registered Industrial Property Rights (registered only) (0)

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6. Symposia (1)

No. Date Organizer Program Title Contents Place Attendees
1 Oct. 26, 2011 Shimadzu US-Japan Cancer Research Open Seminar With the aim of promoting research exchange and accelerating new research, 4 researchers representing the United States and Japan introduced state-of-the-art research on cancer-related genes and proteins, and core researcher Koichi Tanaka presented an overview of the research project.(Details: Topics) 4th Floor, Training Center, Sanjo Works, Head Office of Shimadzu Corporation 90

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7. Outreach Activities (7)

No. Date Organizer Program Title Contents Place Attendees
1 Apr. 18, 2011 Shimadzu (issued by Kagaku-Dojin Publishing Company, INC) Symposium: Breakthroughs in Analytical Instruments – Progress in the Last 10 Years and into the Future An introduction to mass spectrometry techniques by General Manager Tanaka Kagaku (Chemistry supplement), p. 2 to 16 -
2 May 19, 2011 Shimadzu (sponsored by the Mass Spectrometry Society of Japan) 137th Mass Spectrometry Society of Japan, Kanto-Area Conference Koichi Tanaka outlined details of this project, presented results for the first year, and described the research and development of mass spectrometers as a “place” to foster young talent. Hatsumeikaikan Hall 70
3 May 20, 2011 Shimadzu (sponsored by the Science Council of Japan) Observing, Measuring, Knowing –– World Opened Up by Leading-Edge Measurement and Analytical Techniques Koichi Tanaka outlined details of this project, presented results for the first year, and described the research and development of mass spectrometers as a “place” to foster young talent.（Details: Topics articles） Auditorium, Science Council of Japan 170
4 Aug. 22, 2011 Shimadzu (sponsored by Toyama Prefecture) Toyama Scientific Lecture Based on the experience obtained particularly with young researchers and engineers through research on this leading-edge project, Koichi Tanaka discussed how thoroughly learning and applying the fundamentals from high school can lead to world-class discoveries.（Details: Topics articles） Toyama Kenminkaikan Hall 100
5 Aug. 26, 2011 Kyoto University (sponsored by the Japan Human Proteome Organization) Japan Human Proteome Organization Newsletter The Japan Human Proteome Organization Newsletter No. 74 described the research being conducted at the Koichi Tanaka Laboratory of Advanced Science and Technology and the World-Leading Drug Discovery Research Center, Kyoto University. Japan Human Proteome Organization web site (published article) -
6 Jan. 9, 2012 Shimadzu (sponsored by the Science Council of Japan) Open symposium “Aiming Toward the Development of Structural Life Science Through the Advanced Interdisciplinary Collaboration” While Koichi Tanaka described progress made in this project, he explained that mass spectrometry in recent years has progressed along with development of structural life science, and stressed the importance of interdisciplinary collaboration.（Details: Topics articles） Science Council of Japan Symposium 300
7 Feb. 6, 2012 Shimadzu (issued by Nikkei Business Publications, Inc.) Feature: The War Against Cancer: The Time is Ripe for a Leap in Medical Treatment An interview with fellow Tanaka, and an introduction to the achievements of the FIRST Program (Details: Topics articles) Nikkei Electronics, p. 38 to 39, 44 -

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8. Media Coverage & Publicity (14): TV (2), Newspapers (10), Magazines (NOT Journal Paper) (0), Others (2)

No. Types of Media Broadcaster / Publisher Program Name / Title Broadcast / Publication Date Page
1 Newspaper Yomiuri Shimbun Young Researchers Interact with Nobel Laureate, HOPE Meeting Apr. 26, 2011 p. 13
2 Newspaper The Chemical Daily Science Council of Japan, Measurement and Analysis Technology Symposium in the International Year of Chemistry May 24, 2011 p. 11
3 Newspaper Nikkei Shimbun Keizai Kyoshitsu (Economics Classroom) section: Role of Science and Technology –– Learning from the Nuclear Accident: Exploiting the Interdisciplinary Approach（Details: Topics articles） Jun. 1, 2011 p. 29
4 Newspaper Nikkei Shimbun (Evening Paper) Extremely Early Detection of Cancer –– Greatly Enhanced Detection Sensitivity Aug. 10, 2011 p. 1
5 TV Kitanihon Broadcasting Koichi Tanaka’s Scientific Lecture to High-School Students Aug. 22, 2011 News program
6 Newspaper Toyama Shimbun (Yomiuri Shimbun, Kitanihon Shimbun, Hokuriku Chunichi Shimbun, etc.) Koichi Tanaka Delivers Scientific Lecture to Encourage High-School Students –– You Can Do Anything If You Think Outside the Box（Details: Topics articles） Aug. 23, 2011 p. 20
7 Newspaper Yomiuri Shimbun (Nikkei Shimbun, Sankei Shimbun Kyoto Shimbun, etc.) Koichi Tanaka succeeds in identifying substance in body of breast cancer patient （Details: Topics articles） Sep. 9, 2011
8 Newspaper Asahi Shimbun (Nikkei Shimbun, Sankei Shimbun, Mainichi Shimbun, etc.) All kinds of diseases are diagnosed by one blood drop at the early stage – developed by Nobel Prize recipient Koichi Tanaka, et al. –（Details: Topics articles） Nov. 9, 2011 p. 1
9 TV tv asahi Nobel Prize recipient Koichi Tanaka, et al. develop new technology – “diagnose early stage cancer” from 1 drop of blood –（Details: Topics articles） Nov. 10, 2011 News Station
10 web Nikkei Biotech In FIRST Program, Shimadzu Corp. also uses mass spectrometry in research of new antibody （Details: Topics articles） Dec. 8, 2011 Nikkei Biotech
11 Newspaper Kyoto Shimbun Things Forgotten by the Japanese. The Heart of the Japanese, Here in Kyoto （Details: Topics articles） Dec. 18, 2011 p. 9
12 web Nikkei Biotech 2012 New Year outlook, Evaluation Using Multiple Specimens for Applying Results Obtained Through Industry-Academia Collaboration and Joint Research in Diagnosis （Details: Topics articles） Jan. 2, 2012 Nikkei Biotech
13 Newspaper Nikkei Sangyo Shimbun The future created by technology: Hope for Alzheimer prevention （Details: Topics articles） Jan. 10, 2012 p. 1
14 Newspaper The Chemical Daily New Standpoints in Translational Research; Clinical Research Center for Medical Equipment Development, Kyoto University Hospital; “Removing Clinical and Developmental Barriers; To Produce Results by Industry-Academic-Governmental Cooperation” Mar. 21, 2012 p. 5

2010 Research Achievements

1. Journal Papers (2) (Refereed: 2)

  1. Tsuchiya. S. et al. MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-Like 1 (FGFRL1). J. Biol. Chem. 286, 420-428, 2011.
  2. Imanaka Y. et al. MicroRNA-141 Confers Resistance to Cisplatin-induced Apoptosis by Targeting YAP1 in Human Esophageal Squamous Cell Carcinoma. J. Hum. Genet. 2011 Feb3.

2. Presentations (2) (Invited: 0)

  • Yuko Fukuyama, Natsumi Funakoshi, Koichi Tanaka, “High-sensitivity MALDI analyses of glycopeptides using 3-AQ/CHCA as a liquid matrix,” p. 18
    →　Description of a new methodology to detect disease-related glycopeptide compounds at 10 to 100 times higher sensitivity. This is the first fruit of the FIRST research program.
    Presentation materials（482KB）
  • Kaoru Kaneshiro, Yuko Fukuyama, Koichi Tanaka, “High-sensitivity MALDI analyses of glycans by a 3-AQ labeling method in 3-AQ/CHCA liquid matrix,” p. 30
    →　Follow-up report to the report published by the Mass Spectrometry Society of Japan (MSSJ2010 16P-047), “Glycans detection sensitivity increased by several hundred to 10,000 times compared to conventional methods,” as an output from Mass Spectrometry Research Laboratory.
    Presentation materials（524KB）

3. Published Books (0)

4. Symposia (1)

No. Date Organizer Program Title Contents Place Attendees
1 Oct. 30, 2010 Kyoto University The 2nd Kyoto Symposium on the Future of Pharmaceuticals The symposium was intended to introduce the summary of the FIRST research program and its objective to “develop the next-generation mass spectrometer through industry-university cooperation, and contribute to drug discovery and new diagnostic methods.”(Details: Topics) Kyoto University 100

5. Outreach Activities (7)

No. Date Organizer Program Title Contents Place Attendees
1 Apr. 30, 2010 Shimadzu (sponsored by Kyoto University) Activating Creativity Through Inter-Disciplinary Research Koichi Tanaka talked about the importance of inter-disciplinary research from his experience in inventing the Nobel prize winning mass spectrometer.(Details: Topics) Faculty of Engineering, Kyoto University 200
2 Jun. 5, 2010 Shimadzu (sponsored by the Cabinet Office) A Message to You (Science & Technology Festa in Kyoto) From his experiences in high school days through today, Koichi Tanaka talked about the importance of inter-disciplinary research and industry-university-government cooperation to tomorrow’s leaders.(Details：Topics) Kyoto International Conference Center 300
3 Aug. 4, 2010 Shimadzu (sponsored by International Carbohydrate Symposium) International Carbohydrate Symposium-ICS2010 After presenting achievements from his past research, Koichi Tanaka talked about the development of the next-generation mass spectrometer, including glycan analysis. Makuhari Messe Convention Center 300
4 Sep. 6, 2010 Shimadzu (sponsored by Toyama Prefecture) Science and Technology Exchange to Pave the Way to Toyama’s Future Koichi Tanaka introduced his FIRST research project, and exchanged opinions with leaders from local universities and industries.(Details：Topics) Toyama Daiichi Hotel 120
5 Oct. 13, 2010 Shimadzu (sponsored by Tohoku University) What Is Needed to Develop a Next-Generation Mass Spectrometer to Contribute to Medicine and Pharmaceutics? Koichi Tanaka introduced the FIRST research project and exchanged opinions with researchers and students of Tohoku University.(Details:Topics) School of Engineering, Tohoku University 30
6 Oct. 13, 2010 Shimadzu (sponsored by Tohoku University) What Environment Enables Inter-Disciplinary Research? – An Example from Mass Spectrometer Development During his lecture, Koichi Tanaka also referred to the FIRST project, and talked about his theory on how to exhibit creativity in Japan’s research environment.(Details：Topics) Tohoku University Internal Advanced Research and Education Organization 100
7 Oct. 28, 2010 Shimadzu (sponsored by Yomiuri Shimbun and Fukushima Minyu Shimbun) A Forum with a Nobel Laureate – A Message to the Next Generation Koichi Tanaka presented a keynote speech on nurturing young researchers, and then joined a panel discussion.(Details：Topics) College of Engineering, Nihon University (Koriyama, Fukushima Prefecture) 550
8 Mar. 7 to 11, 2011 Shimadzu (sponsored by the Japan Society of the Promotion of Science) 3rd HOPE Meetings Koichi Tanaka gave a speech to graduate students in the Asia Pacific region. Grand Prince Hotel New Takanawa (Minato-ku, Tokyo) 99
9 Mar. 13, 2011 Japan Science and Technology Agency FIRST Science Forum – Leading Scientists and Young Researchers Open Up the Future – Koichi Tanaka gave a lecture at the 3rd forum (in Kyoto) and took part in a panel discussion. Kyoto International Conference Center (Kyoto) 200

6. Media Coverage & Publicity: TV (1), Newspapers (11), Magazines (NOT Journal Paper) (1), Others (3)

No. Types of Media Broadcaster / Publisher Program Name / Title Broadcast / Publication Date Page
1 web Patent Office PR Site 25th Anniversary of the IPR System Project: “Messages from Modern Inventors to Inventors of the Future”
Mr. Tanaka was a featured speaker who communicated the “fun of invention” to a young audience.		 Apr. 2010 Patent Office PR Site
2 Newspaper Asahi Shimbun Keyperson
Mr. Tanaka reviewed the FIRST program and emphasized that it is rewarding to be a researcher and an engineer but they should also be accountable.		 May 7, 2010 p. 7
3 Newspaper Nikkeisangyo Shimbun Changing Research Frontlines – Releasing an Individual’s Talent Of the 30 Core Researchers on the FIRST program, introduces the researchers from the corporate world. Mr. Tanaka was covered in the first story with Dr. Tonomura from Hitachi. May 25, 2010 p. 1, p. 9
4 Others Kyoto University News Establishment of World-Leading Drug Discovery Research Center Introduces the newly established research center at Kyoto University. #656 (May 2010) p. 3176
5 Web Nikkei Shimbun (Yomiuri Online, Mainichi Shimbun, KBSnews, etc.) Nobel laureate speaks on the excitement of science to high-school students. Introduces the contents of his presentation at Science and Technology Festa in Kyoto. Jun. 6, 2010 -
6 Newspaper Nihonkeizai Shimbun Easier Detection of Biomarker Glycans
Explains how the resolution for glycans detection by a few hundred to ten thousand times will lead to earlier detection of diseases and contribute to treatments.		 Jun. 14, 2010 p. 11
7 Newspaper Chunichi Shimbun Behind the Nobel Prize: A Man Who Was Not Afraid of Failure and Believed in Himself
An overview of the message delivered at Science and Technology Festa in Kyoto was introduced in an article aimed at high school students.		 Jun. 29, 2010 p. 9
8 Magazine JST News Report on Science and Technology Festa in Kyoto – Making Science and Technology the Engine to Drive Innovation
Covers Science and Technology Festa in Kyoto over 4 pages.		 Jul. 2010 pp. 6-9
9 Newspaper Kyoto Shimbun A Talk with This Man: Hachiro Sugimoto, an Expert on Drug Discovery
Professor Sugimoto of Kyoto University talks about the difficulties and excitement that come from drug discovery.		 Jul. 4, 2010 p. 18
10 Newspaper Mainichi Shimbun I Saw the Spirit of Challenge in Hayabusa: A dialogue between Junichiro Kawaguchi and Koichi Tanaka.
The Hayabusa Space Probe project showed the importance of fearlessly striving toward our dreams with persistence – a message especially for adults.		 Jul. 15, 2010 p. 18
11 Newspaper Asahi Shimbun Computer Age for Bio Researchers
Professor Tsujimoto of Kyoto University explains the current trends in genetic diagnosis and treatment as applied fields of bioinformatics.		 Aug. 10, 2010 p. 26
12 Newspaper Nikkeisangyo Shimbun Technology Leads the Way to Japan’s Future
Three core researchers from the FIRST project –– Mr. Tanaka of Shimadzu, Dr. Nakayama of Kyoto University, and Dr. Tonomura of Hitachi –– are introduced as having high industry expectations.		 Aug. 30, 2010 p. 19
13 TV Kitanihon Broadcasting Science & Technology Exchange with Koichi Tanaka
Introduces the Science & Technology exchange event held in Toyama.		 Sep. 6, 2010 News program
14 Newspaper Toyama Shimbun, Kitanihon Shimbun, etc. The Secret of Turning Failure into Success
The Nobel laureate Koichi Tanaka spoke at the Science & Technology exchange event in Toyama.		 Sep. 7, 2010 Toyama Shimbun article
15 Newspaper Yomiuri Shimbun Showing Japan’s Scientific Competence
Telephone dialogue between Nobel laureates, Dr. Suzuki, Dr. Esaki and Mr. Tanaka		 Oct. 7, 2010 p. 6
16 Newspaper Yomiuri Shimbun – Tokyo edition A Forum with a Nobel Laureate –– A Message to the Next Generation at Nihon University Nov. 12, 2010 pp. 22, 23
Yomiuri Shimbun (Evening Paper) Osaka Edition Nov. 22, 2010 Details of article
17 Newspaper Nikkei Shimbun (Evening Paper) Hayabusa Returns Itokawa Asteroid Particles to Earth
（Koichi Tanaka commented, “I am happy science and technology contributed to this dream. Industry making these challenges while dealing with failures shows the way to the future.”）		 Nov. 16, 2010 p. 14
18 Magazine Chemical Monthly (March Issue) Symposium: Breakthroughs in Analytical Instruments –– Progress in the Last 10 Years and into the Future Feb. 18, 2011 March 2011 Edition
19 Newspaper Kyoto Shimbun Talk on the Way of Scientific Research to High-School Students Mar. 14, 2011 p. 21

2009 Research Achievements

1. Journal Papers (0) (Refereed: 0)

2. Presentations (0) (Invited: 0)

3. Published Books (0)

4. Symposia (0)

5. Outreach Activities (2)

No. Date Organizer Program Title Contents Place Attendees
1 Sep. 26, 2009 Shimadzu (sponsored by Mass Spectrometry Society of Japan) 118th Mass Spectrometry Meeting in Kansai Explained the outline of the FIRST research program to Kansai area MS researchers. Osaka Prefecture University 40
2 Oct. 1, 2009 Shimadzu (sponsored by Japanese Cancer Association) Special Lecture –– Can Cancer Be Diagnosed by Mass Spectrometer? Introduced the FIRST research program at the 68th Annual Meeting of the Japanese Cancer Association. Pacifico Yokohama 300

6. Media Coverage & Publicity: TV (0), Newspapers (2), Magazines (NOT Journal Paper) (1), Others (0)

No. Type of Media Broadcaster / Publisher Program Name / Title Broadcast / Publication Date Page
1 Newspaper Nikkei Shimbun Improving Detection Resolution 1,000 Times for Disease-Related Proteins in Blood
Describes how the FIRST program was started for joint development by Shimadzu and Kyoto University of the next-generation MS system to contribute toward drug discovery for cancer and Alzheimer’s disease.		 Sep. 14, 2009 p. 13
2 Newspaper Yomiuri Shimbun Searching for Substances to Solve the Mystery of Disease
Describes how the FIRST program focuses not only on research, but also on the training of young researchers.		 Sep. 28, 2009 p. 22
3 Magazine Science Window With Your Own Experiment, You Can See Something Beyond Failure
Describes the importance of learning from failed experiments in a magazine designed for teachers of science.		 Feb. 2009 (2010 Early Spring Issue) pp. 6, 7（380KB）