2011

1. Journal Papers (4) (refereed: 4)

  1. Kaoru Kaneshiro, Yuko Fukuyama, Shinichi Iwamoto, Sadanori Sekiya, and Koichi Tanaka
     Koichi Tanaka Mass Spectrometry Research Laboratory and Koichi Tanaka Laboratory of Advanced Science and Technology*)
    “Highly Sensitive MALDI Analyses of Glycans by a New Aminoquinoline-Labeling Method Using 3-Aminoquinoline/α-Cyano-4-hydroxycinnamic Acid Liquid Matrix”
    Analytical Chemistry., 2011, Vol. 83 No.10, pp3663-3667
    Presentation materials
    *)Affiliated with both organizations, as the Koichi Tanaka Laboratory of Advanced Science and Technology took over research from the Koichi Tanaka Mass Spectrometry Research Laboratory.
  2. Takashi Shimada1,2, Atsuhiko Toyama1, Chikage Aoki1, Yutaka Aoki1, Koichi Tanaka2,3, Taka-Aki Sato1,2
    “Direct antigen detection from immunoprecipitated beads using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; a new method for immunobeads-mass spectrometry (iMS)”, Rapid Commun. Mass Spectrom. 2011, 25, pp3521-3526
    1 Life Science Research Center, Shimadzu Corporation
    2 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    3 Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation
  3. Daniel J. CAPON1, Naoki KANEKO2, Takayuki YOSHIMORI2, Takashi SHIMADA2, Florian M. WURM3, Peter K. HWANG4, Xiaohe TONG5, Staci A. ADAMS1, Graham SIMMONS1, Taka-Aki SATO2 and Koichi TANAKA2
    “Flexible antibodies with nonprotein hinges”, Proceedings of the Japan Academy, Series B, Vol. 87 pp603-616 (2011)
    1 Blood Systems Research Institute, San Francisco, U.S.A.
    2 Koichi Tanaka Laboratory of Advanced Science and Technology, Kyoto, Japan.
    3 Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
    4 University of California, San Francisco, California, U.S.A.
    5 CPC Scientific, Sunnyvale, California, U.S.A.
  4. Takashi Shimada1,2, Hiroki Kuyama1, Taka-Aki Sato1,2, Koichi Tanaka1
    “Development of iodoacetic acid-based cysteine mass tags: Detection enhancement for cysteine-containing peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry”, Analytical Biochemistry, 2012, Issue 2, pp785-787
    1 SHIMADZU Corporation, Koichi Tanaka Laboratory of Advanced Science and Technology
    2 SHIMADZU Corporation, Life Science Research Center

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2. Presentations (20) (Invited: 0)

  1. [ThP583] Yuko Fukuyama1, Natsumi Funakoshi1, Shinichi Iwamoto1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    Highly sensitive MALDI analyses of glycopeptides using liquid matrices 3-AQ/CHCA and 3-AQ/CA, 59th ASMS Conference on Mass Spectrometry and Allied Topics, June 5 – 9, 2011
    → Describes the highly sensitive analysis of glycopeptides to 10 amol max. (100 times greater than before) using the newly developed liquid matrix 3-AQ/CHCA.
    Presentation materials(383KB)
  2. [MP445] Kentaro Morimoto1, Masaki Murase1, Tsuyoshi Tabata2, Shigeki Kajihara1, Yoshiya Oda2, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd.
    Peptide search algorithm by selecting and rescoring reliable peaks for MSn(n>1) spectra, 59th ASMS Conference on Mass Spectrometry and Allied Topics, June 5 – 9, 2011
    → Normally, only MS/MS data is referenced to obtain peptide sequence information. However, this presentation illustrates that the identification rate can be enhanced by combining MS3 and higher information and introduces the associated algorithms.
    Presentation materials(287KB)
  3. [ThP383] Satoshi Tanaka1, Shigeki Kajihara1, Shinichi Utsunomiya1, Tsuyoshi Tabata2, Ken Aoshima2, Yoshiya Oda2, Yoshito Nihei3, Takaaki Nishioka3 , Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd., 3 BIRD, JST, Keio University
    Development of a client tool for a mass spectra database, 59th ASMS Conference on Mass Spectrometry and Allied Topics, June 5 – 9, 2011
    → Mass++ is free software for viewing and analysis in mass spectrometry. Plug-in software was developed to connect Mass++ with the MassBank free database, simplifying the searching of large data sets.
    Presentation materials(1,631KB)
  4. [1P-09] Yusaku Hioki1, Yuko Fukuyama1, Chikako Hamana1, Shinichi Iwamoto1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Improving the Sensitivity in MALDI-MS Analyses by Using Deposition of Small Droplet”, The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  5. [1P-12] Kaoru Kaneshiro1, Makoto Watanabe1, Kazuya Terasawa2, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 World-Leading Drug Discovery Research Center, Faculty of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University
    “N-Glycan profiling of HER2 by AQlabeling method with 3-AQ/CHCA liquid matrix,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  6. [1P-40] Yuko Fukuyama1, Natsumi Funakoshi1, Shinichi Iwamoto1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Highly sensitive MALDI analyses of glycopeptides using liquid matrices 3-AQ/CHCA and 3-AQ/CA,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  7. [1P-49] Kei Kodera1, Masafumi Jinno1, Kiyoshi Watanabe1, Makoto Hazama1, Masaji Furuta1, Sadanori Sekiya1, Kaori Kinoshita1, Hidenori Takahashi1, Kosuke Hosoi1, Toshinori Kobayashi1, Shinichi Iwamoto1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “MALDI-Digital-Ion-Trap-TOFMS with Ion Trap Pass-through TOF Mode,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  8. [2P-01] Howell Parry1, Satoshi Tanaka1, Tsuyoshi Tabata2, Ken Aoshima2, Yoshiya Oda2, Yoshito Nihei3, Takaaki Nishioka3, Shinichi Utsunomiya1, Shigeki Kajihara11 Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd., 3 Nara Institute of Science and Technology
    “Mass++ 2.0.0: New version of freeware mass spectrometry analysis software,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  9. [2P-11] Kenichi Taniguchi1, Yuko Fukuyama1, Yutaka Ibuki1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Highly sensitive analysis of glycopeptides using labeling technique by MALDI-MS,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  10. [2P-24] Takashi Shimada1, Taka-Aki Sato1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Development of novel MS probes for high-sensitivity proteomics,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  11. [2P-40] Yuko Fukuyama1, Ritsuko Tanimura1, Shunsuke Izumi2, Shinichi Iwamoto1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Graduate School of Science, Hiroshima University
    “Highly sensitive MALDI analyses of hydrophobic peptides using a novel additive ADHB with conventional matrices,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  12. [3P-01] Kentaro Morimoto1, Masaki Murase1, Tsuyoshi Tabata2, Shigeki Kajihara1, Ken Aoshima2, Yoshiya Oda2, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd.
    “Evaluation of a novel database search algorithm using MSn spectra,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  13. [3P-21] Akiyasu Yoshizawa1, Tsuyoshi Tabata2, Takayuki Kimura2, Ken Aoshima2, Yoshiya Oda2, Shigeki Kajihara1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology, 2 Eisai Co., Ltd.
    “Application of post-translational modification information in database search,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  14. [3P-26] Kazuya Terasawa1, Hiromasa Uchimura1, Kaoru Kaneshiro2, Makoto Watanabe2, Kazuharu Shimizu1, Gozoh Tsujimoto1, Koichi Tanaka2
     1 World-Leading Drug Discovery Research Center, Faculty of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, 2 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Estimation of HER2 N-glycosylation ratio using MALDI MS,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  15. [3P-40] Yuko Fukuyama1, Kohei Takeyama1, Shinichi Iwamoto1, Koichi Tanaka1
     1 Koichi Tanaka Laboratory of Advanced Science and Technology
    “Highly sensitive MALDI analyses of phosphorylated peptides using an optimized liquid matrix 3-AQ/CHCA,” The 59th Annual Conference on Mass Spectrometry, Sep. 13–15, 2011
  16. [2P-0344] Akiyasu Yoshizawa1, Tsuyoshi Tabata2, Takayuki Kimura2, Ken Aoshima2, Yoshiya Oda2, Shigeki Kajihara1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 EPCS, Eisai Co., Ltd.
    “Application of post-translational modification information in MS database search,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  17. [2P-0395] Kaoru Kaneshiro1, Makoto Watanabe1, Yuko Fukuyama1, Kazuya Terasawa2, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Taka-Aki Sato1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 Graduate School of Pharmaceutical Sciences, Kyoto University
    “N-glycan profiling of HER2 by AQ-labeling method with 3-AQ/CHCA liquid matrix,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  18. [2P-0396] Kazuya Terasawa1, Hiromasa Uchimura1, Kaoru Kaneshiro2, Makoto Watanabe2, Yuko Fukuyama2, Kazuharu Shimizu1, Gozoh Tsujimoto1, Taka-Aki Sato2, Koichi Tanaka2
    1 Graduate School of Pharmaceutical Sciences, Kyoto University
    2 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    “Estimation of HER2 N-glycosylation ratio using MALDI MS,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  19. [2P-0397] Makoto Watanabe1, Kazuya Terasawa2, Kaoru Kaneshiro1, Yuko Fukuyama1, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Taka-Aki Sato1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 Graduate School of Pharmaceutical Sciences, Kyoto University
    “Phosphorylated peptide analysis of HER2 using a liquid matrix 3-AQ/CHCA,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011
  20. [4P-0634] Yuko Fukuyama1, Kaoru Kaneshiro1, Makoto Watanabe1, Kazuya Terasawa2, Hiromasa Uchimura2, Kazuharu Shimizu2, Gozoh Tsujimoto2, Taka-Aki Sato1, Koichi Tanaka1
    1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
    2 Graduate School of Pharmaceutical Sciences, Kyoto University
    “Phosphorylated peptide analysis of HER2 using a liquid matrix 3-AQ/CHCA,” 34th Annual Meeting of the Molecular Biology Society, December 13–16, 2011

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3. Published Books (0)

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4. Industrial Property Rights Applications (pending but unregistered only) (24)

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5. Registered Industrial Property Rights (registered only) (0)

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6. Symposia (1)

No. Date Organizer Program Title Contents Place Attendees
1 Oct. 26, 2011 Shimadzu US-Japan Cancer Research Open Seminar With the aim of promoting research exchange and accelerating new research, 4 researchers representing the United States and Japan introduced state-of-the-art research on cancer-related genes and proteins, and core researcher Koichi Tanaka presented an overview of the research project.(Details: Topics) 4th Floor, Training Center, Sanjo Works, Head Office of Shimadzu Corporation 90

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7. Outreach Activities (7)

No. Date Organizer Program Title Contents Place Attendees
1 Apr. 18, 2011 Shimadzu (issued by Kagaku-Dojin Publishing Company, INC) Symposium: Breakthroughs in Analytical Instruments – Progress in the Last 10 Years and into the Future An introduction to mass spectrometry techniques by General Manager Tanaka Kagaku (Chemistry supplement), p. 2 to 16 -
2 May 19, 2011 Shimadzu (sponsored by the Mass Spectrometry Society of Japan) 137th Mass Spectrometry Society of Japan, Kanto-Area Conference Koichi Tanaka outlined details of this project, presented results for the first year, and described the research and development of mass spectrometers as a “place” to foster young talent. Hatsumeikaikan Hall 70
3 May 20, 2011 Shimadzu (sponsored by the Science Council of Japan) Observing, Measuring, Knowing –– World Opened Up by Leading-Edge Measurement and Analytical Techniques Koichi Tanaka outlined details of this project, presented results for the first year, and described the research and development of mass spectrometers as a “place” to foster young talent.(Details: Topics articles) Auditorium, Science Council of Japan 170
4 Aug. 22, 2011 Shimadzu (sponsored by Toyama Prefecture) Toyama Scientific Lecture Based on the experience obtained particularly with young researchers and engineers through research on this leading-edge project, Koichi Tanaka discussed how thoroughly learning and applying the fundamentals from high school can lead to world-class discoveries.(Details: Topics articles) Toyama Kenminkaikan Hall 100
5 Aug. 26, 2011 Kyoto University (sponsored by the Japan Human Proteome Organization) Japan Human Proteome Organization Newsletter The Japan Human Proteome Organization Newsletter No. 74 described the research being conducted at the Koichi Tanaka Laboratory of Advanced Science and Technology and the World-Leading Drug Discovery Research Center, Kyoto University. Japan Human Proteome Organization web site (published article) -
6 Jan. 9, 2012 Shimadzu (sponsored by the Science Council of Japan) Open symposium “Aiming Toward the Development of Structural Life Science Through the Advanced Interdisciplinary Collaboration” While Koichi Tanaka described progress made in this project, he explained that mass spectrometry in recent years has progressed along with development of structural life science, and stressed the importance of interdisciplinary collaboration.(Details: Topics articles) Science Council of Japan Symposium 300
7 Feb. 6, 2012 Shimadzu (issued by Nikkei Business Publications, Inc.) Feature: The War Against Cancer: The Time is Ripe for a Leap in Medical Treatment An interview with fellow Tanaka, and an introduction to the achievements of the FIRST Program (Details: Topics articles) Nikkei Electronics, p. 38 to 39, 44 -

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8. Media Coverage & Publicity (14): TV (2), Newspapers (10), Magazines (NOT Journal Paper) (0), Others (2)

No. Types of Media Broadcaster / Publisher Program Name / Title Broadcast / Publication Date Page
1 Newspaper Yomiuri Shimbun Young Researchers Interact with Nobel Laureate, HOPE Meeting Apr. 26, 2011 p. 13
2 Newspaper The Chemical Daily Science Council of Japan, Measurement and Analysis Technology Symposium in the International Year of Chemistry May 24, 2011 p. 11
3 Newspaper Nikkei Shimbun Keizai Kyoshitsu (Economics Classroom) section: Role of Science and Technology –– Learning from the Nuclear Accident: Exploiting the Interdisciplinary Approach(Details: Topics articles) Jun. 1, 2011 p. 29
4 Newspaper Nikkei Shimbun (Evening Paper) Extremely Early Detection of Cancer –– Greatly Enhanced Detection Sensitivity Aug. 10, 2011 p. 1
5 TV Kitanihon Broadcasting Koichi Tanaka’s Scientific Lecture to High-School Students Aug. 22, 2011 News program
6 Newspaper Toyama Shimbun (Yomiuri Shimbun, Kitanihon Shimbun, Hokuriku Chunichi Shimbun, etc.) Koichi Tanaka Delivers Scientific Lecture to Encourage High-School Students –– You Can Do Anything If You Think Outside the Box(Details: Topics articles) Aug. 23, 2011 p. 20
7 Newspaper Yomiuri Shimbun (Nikkei Shimbun, Sankei Shimbun Kyoto Shimbun, etc.) Koichi Tanaka succeeds in identifying substance in body of breast cancer patient (Details: Topics articles) Sep. 9, 2011
8 Newspaper Asahi Shimbun (Nikkei Shimbun, Sankei Shimbun, Mainichi Shimbun, etc.) All kinds of diseases are diagnosed by one blood drop at the early stage – developed by Nobel Prize recipient Koichi Tanaka, et al. –(Details: Topics articles) Nov. 9, 2011 p. 1
9 TV tv asahi Nobel Prize recipient Koichi Tanaka, et al. develop new technology – “diagnose early stage cancer” from 1 drop of blood –(Details: Topics articles) Nov. 10, 2011 News Station
10 web Nikkei Biotech In FIRST Program, Shimadzu Corp. also uses mass spectrometry in research of new antibody (Details: Topics articles) Dec. 8, 2011 Nikkei Biotech
11 Newspaper Kyoto Shimbun Things Forgotten by the Japanese. The Heart of the Japanese, Here in Kyoto (Details: Topics articles) Dec. 18, 2011 p. 9
12 web Nikkei Biotech 2012 New Year outlook, Evaluation Using Multiple Specimens for Applying Results Obtained Through Industry-Academia Collaboration and Joint Research in Diagnosis (Details: Topics articles) Jan. 2, 2012 Nikkei Biotech
13 Newspaper Nikkei Sangyo Shimbun The future created by technology: Hope for Alzheimer prevention (Details: Topics articles) Jan. 10, 2012 p. 1
14 Newspaper The Chemical Daily New Standpoints in Translational Research; Clinical Research Center for Medical Equipment Development, Kyoto University Hospital; “Removing Clinical and Developmental Barriers; To Produce Results by Industry-Academic-Governmental Cooperation” Mar. 21, 2012 p. 5