[SHIMADZU] 業績 | 大阪大学・島津分析イノベーション協働研究所

2024.01

A Bayesian approach for constituent estimation in nucleic acid mixture models

Front. Anal. Sci., 08 Jan 2024, 10.3389/frans.2023.1301602

Taichi Tomono^1,2,3
Satoshi Hara¹
Yusuke Nakai²
Kazuma Takahara²
Junko Iida^3,4
Takashi Washio¹

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¹Department of Reasoning for Intelligence, The Institute of Scientific and Industrial Research, Osaka University, Ōsaka, Japan
²AI Solution Unit, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan
³Shimadzu Analytical Innovation Research Laboratories, Osaka University, Ōsaka, Japan
⁴Life Science Business Department, Analytical and Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

2023.11

Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study

J Chromatogr A 1708(2023) 464333.

Momoka　Hayashida^1,2,3
Risa Suzuki³
Shinnosuke Horie^2,3,4
Junichi Masuda³
Takao Yamaguchi¹
Satoshi Obika¹

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¹Graduate School of Pharmaceutical Sciences, Osaka University
²Shimadzu Analytical Innovation Research Laboratories
³Shimadzu Corporation
⁴Shimadzu Europa GmbH

2023.10

Lipidome and metabolome analyses reveal metabolic alterations associated with MCF-7 apoptosis upon 4-hydroxytamoxifen treatment

Sci. Rep. (2023) 13:18549

Kazuki Nishimoto¹
Nobuyuki Okahashi^1,2,3
Masaharu Maruyama¹
Yoshihiro Izumi⁴
Kohta Nakatani⁴
Yuki Ito^2,5
Junko Iida^2,5
Takeshi Bamba⁴
Fumio Matsuda^1,2,3

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¹Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
²Department of Biotechnology, Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
³Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
⁴Division of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University
⁵Analytical and Measuring Instruments Division, Shimadzu Corporation

2023.02

Lipidome variation of industrial Saccharomyces cerevisiae strains analyzed by LC-QTOF/MS-based untargeted lipidomics

J Biosci Bioeng, 135(2) 102-108

Shuka Komori¹
Nobuyuki Okahashi^{1 2 3}
Junko Iida^{2 4}
Fumio Matsuda^{1 2 3}

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¹Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
²Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
³Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
⁴Analytical and Measuring Instruments Division, Shimadzu Corporation

2022.07

Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform

Metabolites 2022, 12(7), 646

Nobuyuki Okahashi^{1 2 3}
Yuki Yamada¹
Junko Iida^{2 4}
Fumio Matsuda^{1 2 3}

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¹Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
²Department of Biotechnology, Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
³Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
⁴Analytical and Measuring Instruments Division, Shimadzu Corporation

2022.01

Automated Recommendation of Research Keywords from PubMed That Suggest the Molecular Mechanism Associated with Biomarker Metabolites

Metabolites

Shinji Kanazawa^1,2,3
Satoshi Shimizu¹
Shigeki Kajihara¹
Norio Mukai¹
Junko Iida^1,2
Fumio Matsuda^3,4

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¹Shimadzu Corporation
²Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University
³Graduate School of Information Science and Technology, Osaka University
⁴Institute for Open and Transdisciplinary Research Initiatives, Osaka University

2021.05

Evaluation of change in metabolome caused by comprehensive diabetes treatment: A prospective observational study of diabetes inpatients with gas chromatography/mass spectrometry-based non-target metabolomic analysis

journal of diabetes investigation

Naohiro Taya¹
Naoto Katakami^1,2
Kazuo Omori¹
Shoya Arakawa³
Shigero Hosoe¹
Hirotaka Watanabe¹
Mitsuyoshi Takahara^1,4
Kazuyuki Miyashita¹
Hitoshi Nishizawa¹
Taka-Aki Matsuoka¹
Masahiro Furuno³
Takeshi Bamba⁵
Junko Iida^6,7
Eiichiro Fukusaki³
Iichiro Shimomura¹

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¹Department of Metabolic Medicine, Osaka University Graduate School of Medicine
²Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine
³Laboratory of Bioresource Engineering, Department of Biotechnology, Graduate School of Engineering, Osaka University
⁴Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University
⁵Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
⁶Shimadzu Corporation
⁷Osaka University Shimadzu Omics Innovation Research Laboratories, Graduate School of Engineering, Osaka University

2021.02

Fake metabolomics chromatogram generation for facilitating deep learning of peak-picking neural networks

Journal of Bioscience and Bioengineering

Shinji Kanazawa^1,2,3
Akira Noda¹
Arisa Ito²
Kyoko Hashimoto²
Akihiro Kunisawa¹
Tsuyoshi Nakanishi¹
Shigeki Kajihara¹
Norio Mukai¹
Junko Iida^1,2
Eiichiro Fukusaki⁴
Fumio Matsuda³

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¹Shimadzu Corporation
²Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University
³Graduate School of Information Science and Technology, Osaka University
⁴Graduate School of Engineering, Osaka University

2019.08

Fragmentation of Dicarboxylic and Tricarboxylic Acids in the Krebs Cycle Using GC-EI-MS and GC-EI-MS/MS

Mass Spectrometry

Nobuyuki Okahashi¹
Shuichi Kawana²
Junko Iida^2,3
Hiroshi Shimizu¹
Fumio Matsuda¹

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¹Graduate School of Information Science and Technology, Osaka University
²Shimadzu Corporation
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

2018.12

Free D-amino acids produced by commensal bacteria in the colonic lumen

Scientific Reports (2018), DOI:10.1038/s41598-018-36244-z

Mitsuharu Matsumoto¹
Akihiro Kunisawa^2,3
Takanari Hattori^2,3
Shuichi Kawana²
Yusuke Kitada¹
Hazuki Tamada¹
Shinichi Kawano^2,3
Yoshihiro Hayakawa²
Junko Iida^2,3
Eiichiro Fukusaki^3,4

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¹Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd
²Shimadzu Corporation
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
⁴Graduate School of Information Science and Technology, Osaka University

2018.09

Sugar phosphate analysis with baseline separation and soft ionization by gas chromatography-negative chemical ionization-mass spectrometry improves flux estimation of bidirectional reactions in cancer cells

Metabolic Engineering (2018)

Nobuyuki Okahashi¹
Kousuke Maeda¹
Shuichi Kawana²
Junko Iida^2,3
Hiroshi Shimizu¹
Fumio Matsuda¹

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¹Graduate School of Information Science and Technology, Osaka University
²Shimadzu Corporation
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

2018.08

FK960 binding proteins, quinone oxidoreductase2 and pyridoxal kinase were identified by LC-MS/MS for drug discovery of Alzheimer's treatment

Trends in Research (2018), DOI:10.15761/TR.1000113

Zenzaburo Tozuka^1,2,3
Akihiro Kunisawa²
Fumiyuki Shirai^3,4
Yoshinori Ishii^3,4

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¹Graduate School of Pharmaceutical Science, Osaka University
²Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
³Fujisawa Pharmaceutical Co., Ltd.
⁴Astellas Pharma Inc.

2018.07

Multi omics by LC-MS/MS to search small molecule ligands of nuclear receptors to control transcription of pharmaceutical active proteins for drug discovery

Trends in Research (2018), DOI: 10.15761/TR.1000111

Zenzaburo Tozuka, Akihiro Kunisawa

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Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

2016.06

GC-MS/MS survey of collision-induced dissociation of tert-butyldimethylsilyl-derivatized amino acids and its application to 13C-metabolic flux analysis of Escherichia coli central metabolism

Analytical and Bioanalytical Chemistry, June, 2016, in press.

Nobuyuki Okahashi¹
Shuichi Kawana²
Junko Iida^2,3
Hiroshi Shimizu¹
Fumio Matsuda¹

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¹Graduate School of Information Science and Technology, Osaka University
²Shimadzu Co.
³Graduate School of Engineering, Osaka University