論文

2026

Characterization of flavor quality in sago starch produced by different processing methods: Insights from physicochemical, metabolomic, and sensory analyses

J Biosci Bioeng.

  • Giri R. Barokah1 2
  • Azis B. Sitanggang3
  • Eiichiro Fukusaki1 4 5
  • Sastia P. Putri1 4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Research Center for Food Technology and Processing, National Research and Innovation Agency
  3. 3 Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, IPB University
  4. 4 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  5. 5 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University

Prediction of the current state of beer fermentation indicators using volatile organic compounds from fermentation gas

Journal of Bioscience and Bioengineering

  • Keisuke Yamauchi1
  • Fumika Kimura1
  • Masahiro Furuno1
  • Keijiro Tamaru2
  • Kosuke Honda2
  • Eiichiro Fukusaki1 3 4
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka
  2. 2 International Center for Biotechnology, The University of Osaka
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, The University of Osaka
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratories, The University of Osaka

Metabolomics-based investigation of compounds associated with sensory profiles of strawberries

Journal of Bioscience and Bioengineering

  • Yuri Yoshiyama1
  • Taichiro Fujimura2
  • Masahiro Furuno1
  • Eiichiro Fukusaki1 3 4
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka
  2. 2 Department of Food and Nutrition, Faculty of Contemporary Human Life Science, Tezukayama University
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, The University of Osaka
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratories, The University of Osaka

GC-MS-Based Metabolite Profiling Method for Tea

Gas Chromatography-Mass Spectrometry

  • Enik Nurlaili Afifah
  • Shunsuke Miyauchi
  • & Eiichiro Fukusaki
  1. Department of Biotechnology, Graduate School of Engineering, The University of Osaka, Suita, Osaka, Japan
  2. Department of Agronomy, Faculty of Agriculture, Universitas Gadjah Mada, Yogyakarta, Indonesia
  3. Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Suita, Osaka, Japan
  4. The University of Osaka Shimadzu Omics Innovation Research Laboratories, International Center for Biotechnology, The University of Osaka, Suita, Osaka, Japan

Non-destructive prediction of banana ripeness using GC-MS-based volatile organic compounds profiling and orthogonal partial-least squares regression models

J Biosci Bioeng.

  • Sayaka Togami1
  • Takumi Oishi1
  • Masahiro Furuno1
  • Eiichiro Fukusaki1 2 3
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka
  2. 2 The University of Osaka Shimadzu Omics Innovation Research Laboratories, The University of Osaka
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, The University of Osaka

Spatiotemporal Dynamics of Polyphenolic Compounds in Musa spp. during Ripening Revealed by Mass Spectrometry Imaging

J Agric Food Chem.

  • Hiroko Shinoda1
  • Shiho Ishimoto1
  • Eiichiro Fukusaki1 2 3
  • Shuichi Shimma1 2 3
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka.
  2. 2 The University of Osaka and Shimadzu Analytical Innovation Research Laboratory, The University of Osaka.
  3. 3 Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka.

Hydrophilic additives enhancing electrospray ionization of oligonucleotides in hexafluoro-2-propanol-free reversed-phase ion-pair liquid chromatography/mass spectrometry

Journal of Chromatography A

  • Takashi Miyazaki1 2 3
  • Natsuyo Asanoo3
  • Satoshi Yamaki3
  • Takao Yamaguchi1
  • Satoshi Obika1
  1. 1 Graduate School of Pharmaceutical Sciences, The University of Osaka
  2. 2 Shimadzu Analytical Innovation Research Laboratories, The University of Osaka
  3. 3 Shimadzu Corporation

2025

Exploration of Key Flavor Compounds in Five Grilled Salmonid Species by Integrating Volatile Profiling and Sensory Evaluation

Metabolites

  • Yuka Mori1,2
  • Akimasa Hatanaka2
  • and Eiichiro Fukusaki1,3
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka
  2. 2 Central Research Laboratory, Nissui Corporation
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratories, The University of Osaka

Redefining media blending mathematically: a systematic approach for screening of medium components

Applied Microbiology and Biotechnology

  • Hirotaka Kuroda1 2 3
  • Kazuya Sorada1 2 3
  • Noriko Yamano-Adachi1 4 5
  • Takeshi Omasa1 4 5
  1. 1 Graduate School of Engineering, Osaka University.
  2. 2 Shimadzu Corp.
  3. 3 Shimadzu Analytical Innovation Research Laboratory, Osaka University.
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University.
  5. 5 Manufacturing Technology Association of Biologics (MAB).

Exploration of Yeast Species Suitable for Preparation of Stable Isotope–Labeled Internal Standards Extracts (SILIS)

Mass Spectrometry

  • Taisuke Seike1,2
  • Kahar Prihardi3
  • Chiaki Ogino3
  • Fumio Matsuda1 2 4
  1. 1 Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, The University of Osaka
  2. 2 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka
  3. 3 Department of Chemical Engineering, Graduate School of Engineering, Kobe University
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, The University of Osaka

Comprehensive GC/MS Profiling of Volatile Organic Compounds in Whole and Glandular Saliva Using MonoTrap Micro-Extraction

Metabolites

  • Asuka Mori1
  • Masae Kuboniwa2
  • Eiichiro Fukusaki1 3
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka
  2. 2 Department of Preventive Dentistry, Graduate School of Dentistry, The University of Osaka
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratories, The University of Osaka

Exploration of yeast species suitable for preparation of stable isotope-labeled internal standards extracts (SILIS)

Mass Spectrometry

  • Taisuke Seike1 2
  • Kahar Prihardi3
  • Chiaki Ogino3
  • Fumio Matsuda1 2 4
  1. 1 Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  3. 3 Department of Chemical Engineering, Graduate School of Engineering, Kobe University
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University

Metabolites and nutritional variations of phenotypic diversity in Kopyor coconut (Cocos nucifera L. var. Kopyor)

J Biosci Bioeng.

  • Mercy Bientri Yunindanova1,2
  • Hengky Novarianto3
  • Eiichiro Fukusaki1,4,5
  • Sastia Prama Putri1,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Study Program of Agrotechnology, Faculty of Agriculture, Universitas Sebelas Maret
  3. 3 National Research and Innovation Agency (BRIN)
  4. 4 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives
  5. 5 Osaka University Shimadzu Analytical Innovation Research Laboratories, International Center for Biotechnology, Osaka University

Metabolite and Sensory Profiling of Microwave-Assisted and Ultrasonic-Assisted Alkalized Cocoa Powders

J Food Sci.

  • Mary Faith Adan1
  • Dimas Rahadian Aji Muhammad2,3
  • Danar Praseptiangga2,3
  • Eiichiro Fukusaki1,4,5
  • Sastia Prama Putri1
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University,
  2. 2 Department of Food Science and Technology, Faculty of Agriculture, Universitas Sebelas Maret
  3. 3 Research Collaboration Center for Traditional Fermentation, Universitas Sebelas Maret
  4. 4 Industrial Biotechnology Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  5. 5 Osaka University-Shimadzu Analytical Innovation Research Laboratories, Osaka University

Microbial Intervention in the Soaking Step during Tempeh Preparation to Modulate B Vitamin Contents: A Metabolomics Approach

Prev Nutr Food Sci.

  • Rifqi Ahmad Riyanto1,2
  • Eiichiro Fukusaki1,3,4
  • Sastia Prama Putri1,3
  1. 1 Department of Biotechnology, Graduate School of Engineering, The University of Osaka
  2. 2 Department of Food Technology, Faculty of Agriculture, Universitas Sultan Ageng Tirtayasa
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratories, The University of Osaka

Metabolomics-based investigation of the differences between traditional and modern soy sauce

J Biosci Bioeng.

  • Yoshika Maekawa1
  • Miki Nakamura2
  • Miho Imamura2
  • Eiichiro Fukusaki1,3,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Research and Development Division, Kikkoman Corporation
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, Osaka University
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University

Metabolic Engineering of the 5-Aminolevulinate Biosynthetic Pathway in E. coli Improves Efficiency of Hemoprotein-Based Biocatalysis

Angew Chem Int Ed Engl.

  • Shunsuke Kato1
  • Miteki Abe1
  • Nobuyuki Okahashi2,3,4
  • Shinya Ariyasu5
  • Fumio Matsuda2,3,4
  • Osami Shoji5
  • Takashi Hayashi1
  1. 1 Department of Applied Chemistry, Graduate School of Engineering, The University of Osaka
  2. 2 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, The University of Osaka
  3. 3 Department of Biotechnology, The University of Osaka and Shimadzu Analytical Innovation Laboratories, Graduate School of Engineering, The University of Osaka
  4. 4 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, The University of Osaka
  5. 5 Department of Chemistry, Graduate School of Science, Nagoya University

Metabolomics reveals the impact of different de-pulping methods on flavor modulation and their potential quality markers in Indonesian cocoa beans

Food Bioscience

  • Aulia Gusning Atia
  • Indah Anita Sarib
  • Hendy Firmantob
  • Abdul Malikb
  • Eiichiro Fukusakia,c,d
  • Sastia Prama Putria,c
  1. a Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. b Indonesian Coffee and Cocoa Research Institute
  3. c Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives
  4. d Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University

ATP Supply from Cytosol to Mitochondria Is an Additional Role of Aerobic Glycolysis to Prevent Programmed Cell Death by Maintenance of Mitochondrial Membrane Potential

Metabolites.

  • Akane Sawai1
  • Takeo Taniguchi1
  • Kohsuke Noguchi1
  • Taisuke Seike1
  • Nobuyuki Okahashi1,2
  • Masak Takaine3,4
  • Fumio Matsuda1,2
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, The University of Osaka
  2. 2 Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, The University of Osaka
  3. 3 Gunma University Initiative for Advanced Research (GIAR), Gunma University
  4. 4 Institute for Molecular and Cellular Regulation (IMCR), Gunma University

電荷検出質量分析による遺伝子治療用ウイルスベクターの特性評価

J. Mass Spectrom. Soc. Jpn.

  • 中塚遼治1,2,3
  1. 1 大阪大学大学院工学研究科
  2. 2 大阪大学・島津分析イノベーション協働研究所
  3. 3 株式会社島津製作所

Correlation between sensory attributes and Metabolomic profiles of cocoa liquor from different cacao genotypes

Food Chem X.

  • Enik Nurlaili Afifah1,2
  • TIndah Anita Sari3
  • Agung Wahyu Susilo3
  • Hendy Firmanto3
  • Abdul Malik3
  • Eiichiro Fukusaki1,4,5
  • Sastia Prama Putri1,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Department of Agronomy, Faculty of Agriculture, Universitas Gadjah Mada
  3. 3 Indonesian Coffee and Cocoa Research Institute
  4. 4 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives
  5. 5 Osaka University Shimadzu Analytical Innovation Research Laboratories, International Center for Biotechnology, Osaka University

Comparative metabolome analysis of sake yeast with enhanced fermentation performance in sake fermentation conditions

J Biosci Bioeng.

  • Kotaro Mori1,2
  • Taisuke Seike1,3
  • Nobuyuki Okahashi1,3,4
  • Toshinari Takahashi2
  • Fumio Matsuda1,3,4
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 General Research Laboratory, Kiku-Masamune Sake Brewing Co. Ltd.
  3. 3 DIndustrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  4. 4 Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University

Data-independent acquisition-based lipidomics reveals lipidome alterations associated with growth of Saccharomyces cerevisiae at low temperature

Journal of Bioscience and Bioengineering

  • Daiki Hara1
  • Nobuyuki Okahashi1,2,3
  • Taisuke Seike1,2
  • Junko Iida3,4
  • Fumio Matsuda1,2,3
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
  4. 4 Analytical and Measuring Instruments Division, Shimadzu Corporation

13C-metabolic flux analysis of Saccharomyces cerevisiae in complex media

Metab Eng Commun.

  • Hayato Fujiwara1
  • Nobuyuki Okahashi1,2,3
  • Taisuke Seike1
  • Fumio Matsuda1,2,3
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University

Gas chromatography-mass spectrometry metabolic profiling and sensory evaluation of greenhouse mangoes (Mangifera indica L. 'Irwin') over multiple harvest seasons

J Biosci Bioeng.

  • Miwa Sato1,2
  • Eiichiro Fukusaki1,3,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Miyazaki Agricultural Research Institute
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University

ΔΔ G Method for Elucidating Key Control Reactions from Relative Quantification Metabolome Data: Comparative Analysis of Yeast Glycolysis

Anal Chem.

  • Fumio Matsuda1,2
  • Ayumu Kamiyama1
  • Kazuki Yamasaki1
  • Taisuke Seike1
  • Nobuyuki Okahashi1,2
  1. 1 Graduate School of Information Science and Technology, Osaka University
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University

Separation of deaminated impurities from the desired oligonucleotides using supercritical fluid chromatography

Journal of Chromatography A

  • 〇Momoka Hayashida1,2,3
  • Risa Suzuki3
  • Shinnosuke Horie2,3,4
  • Junichi Masuda3
  • Takao Yamaguchi1
  • Satoshi Obika1
  1. 1 Graduate School of Pharmaceutical Sciences, Osaka University
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratories
  3. 3 Shimadzu Corporation
  4. 4 Shimadzu Europa GmbH

Biological age prediction using a DNN model based on pathways of steroidogenesis

Science Advances

  • Qiuyi Wang†‡
  • Zi Wang†
  • Kenji Mizuguchi
  • Toshifumi Takao
  1. Institute for Protein Research, Osaka University
  2. † these authors contributed equally to this work.
  3. ‡ Shimadzu corporation.

Application of silica monoliths for improved storage stability of metabolites in human plasma

Journal of Bioscience and Bioengineering

  • Kazuhiro Kawamura1,2,3
  • Eiichiro Fukusaki1,3,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Life Science Business Department, Shimadzu Corporation
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives

Closed genome sequence of Fretibacterium fastidiosum, a potential contributor to periodontal disease

Microbiol Resour Announc.

  • Asuka Morie1
  • Mashu Kudoh2
  • Masae Kuboniwa2
  • Christian Rückert-Reed3,4
  • Tobias Busche3,4
  • Marion Eisenhut3,5
  • Eiichiro Fukusaki1,6,7
  • Andrea Bräutigam3,5
  • Bianca Laker3,5
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University
  3. 3 Center for Biotechnology (CeBiTec), Bielefeld University
  4. 4 Medical School OWL, Bielefeld University, Bielefeld, North Rhine-Westphalia, Germany
  5. 5 Comp utational Biology, Faculty of Biology, Bielefeld University
  6. 6 Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University
  7. 7 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, Osaka University

NCombinatorial Nonribosomal Peptide Synthetase Libraries Using the SEAM-Combi-OGAB Method

ACS Synth Biol.

  • Varada Jagadeesh1
  • Nobuyuki Okahashi2,3
  • Fumio Matsuda2,3
  • Kenji Tsuge1
  • Akihiko Kondo1
  1. 1 Graduate School of Science, Technology, and Innovation, Kobe University.
  2. 2 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University.
  3. 3 Department of Biotechnology, Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University.

Enhancing constituent estimation in nucleic acid mixture models using spectral annealing inference and MS/MS information

Frontiers in Analytical Science

  • Taichi Tomono1,2,3*
  • Satoshi HaraSatoshi Hara4
  • Junko Iida2,5
  • Takashi Washio1,6
  1. 1 The Institute of Scientific and Industrial Research, Osaka University
  2. 2 Shimadzu Analytical Innovation Research Laboratories, Osaka University
  3. 3 AI Solution Unit, Technology Research Laboratory, Shimadzu Corporation
  4. 4 Graduate School of Informatics and Engineering, The University of Electro-Communication
  5. 5 Life Science Business Department, Analytical and Measuring Instruments Division, Shimadzu Corporation
  6. 6 Faculty of Business and Commerce, Kansai University

Metabolic profiling reveals distinctive ripening dynamics in ethylene-treated Musa balbisiana cv. 'Pisang Klutuk Wulung' compared to commercial Cavendish banana

J Biosci Bioeng.

  • Cindy Novianti1,2
  • Lutfi Dewi Nirmala Sari2
  • Husna Nugrahapraja2,3,5
  • Sony Suhandono2,4
  • Fenny Martha Dwivany2,3,4,5
  • Sastia Prama Putri2,6,7
  • Eiichiro Fukusaki6,7,8
  1. 1 Doctoral Program of Biology, School of Life Sciences and Technology, Institut Teknologi Bandung.
  2. 2 School of Life Sciences and Technology, Institut Teknologi Bandung
  3. 3 Biosciences and Biotechnology Research Center, Institut Teknologi Bandung
  4. 4 Nanoscience and Nanotechnology Research Center, Institut Teknologi Bandung
  5. 5 Bali International Research Center for Banana, Gedung Widyasaba, Universitas Udayana
  6. 6 Department of Biotechnology, Graduate School of Engineering, Osaka University
  7. 7 Industrial Biotechnology Division, Institute for Open and Transdisciplinary Research Initiatives
  8. 8 Osaka University-Shimadzu Analytical Innovation Research Laboratories, Osaka University

Gas chromatography–mass spectrometry metabolic profiling and sensory evaluation of greenhouse mangoes (Mangifera indica L. ‘Irwin’) over multiple harvest seasons

Journal of Bioscience and Bioengineering

  • Miwa Sato1,2
  • Eiichiro Fukusaki1,3,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Miyazaki Agricultural Research Institute
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University

2024

Characterization of fine-flavor cocoa in parent-hybrid combinations using metabolomics approach

Food Chem X. Volume 24, 30 December 2024, 101832

  • Enik Nurlaili Afifah1,2
  • Indah Anita Sari3
  • Agung Wahyu Susilo3
  • Abdul Malik3
  • Eiichiro Fukusaki1,4,5
  • Sastia Prama Putri1,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Department of Agronomy, Faculty of Agriculture, Universitas Gadjah Mada
  3. 3 Indonesian Coffee and Cocoa Research Institute
  4. 4 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives
  5. 5 Osaka University Shimadzu Analytical Innovation Research Laboratories, International Center for Biotechnology, Osaka University, 2-1

Imaging Lipidomics and Metallomics of Brown Rice Cultivars Used for Sake Production

Mass Spectrom (Tokyo). 2024;13(1):A0164

  • Eliza Farestiani1
  • Yoshihiro Tamada1,2
  • Koji Okuda3
  • Eiichiro Fukusaki1,4,5
  • Shuichi Shimma1,4,5
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Hakutsuru Sake Brewing Co., Ltd.
  3. 3 Solutions COE, Analytical and Measuring Instruments Division, Shimadzu Corporation
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  5. 5 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

Combination of Probe Electrospray Ionization Mass Spectrometry and Mass Spectrometry Imaging to Analyze Plant Alkaloids in Narcissus tazetta

Mass Spectrom (Tokyo). 2024;13(1):A0163

  • Kaoru Nakagawa1
  • Tetsuo Iida1
  • Manami Kobayashi1
  • Shuichi Shimma2,3
  1. 1 Solutions COE, Analytical & Measuring Instruments Division, Shimadzu Corporation.
  2. 2 Department of Biotechnology, Graduate School of Engineering, Osaka University.
  3. 3 Institute for Open and Transdisciplinary Research Initiatives, Osaka University.

Effect of sodium metabisulfite treatment and storage condition on metabolic profile of young coconut (Cocos nucifera L.)

J Biosci Bioeng. 2024 Dec;138(6):515-521.

  • Kenichi Watanabe1
  • Della Rahmawati1,2
  • Mary Faith Yamballa Adan1
  • Muhammad Maulana Malikul Ikram1
  • Marvin Nathanael Iman1
  • Eiichiro Fukusaki1,3,4
  • Sastia Prama Putri1,3
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Department of Food Technology, Faculty of Life Science and Technology, Swiss German University
  3. 3 Industrial Biotechnology Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  4. 4 Osaka University-Shimadzu Analytical Innovation Research Laboratories, Osaka University

Data Processing of Product Ion Spectra: Methods to Control False Discovery Rate in Compound Search Results for Untargeted Metabolomics

Mass Spectrom (Tokyo). 2024;13(1):A0155

  • Fumio Matsuda1,2
  1. 1 Graduate School of Information Science and Technology, Osaka University.
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University.

Novel mimetic tissue standards for precise quantitative mass spectrometry imaging of drug and neurotransmitter concentrations in rat brain tissues

Anal Bioanal Chem. 2024 Nov;416(26):5579-5593.

  • Kenichi Watanabe1
  • Sayo Takayama1
  • Toichiro Yamada1
  • Masayo Hashimoto1
  • Jun Tadano2
  • Tetsuya Nakagawa2
  • Takao Watanabe3
  • Eiichiro Fukusaki4,5,6
  • Izuru Miyawaki1
  • Shuichi Shimma4,5,6
  1. 1 Preclinical Research Unit, Sumitomo Pharma Co., Ltd.
  2. 2 Research Planning & Coordination, Sumitomo Pharma Co.
  3. 3 Drug Research Division, Sumitomo Pharma Co.
  4. 4 Department of Biotechnology, Graduate School of Engineering, Osaka University.
  5. 5 Institute for Open and Transdisciplinary Research Initiatives, Osaka University.
  6. 6 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University.

Novel sampling and gas-phase derivatization strategy: Proof-of-concept by profiling ionic polar metabolites using gas chromatography-mass spectrometry

J Biosci Bioeng. 2024 Nov;138(5):462-468

  • Kazuhiro Kawamura1,2,3
  • iichiro Fukusaki1,3,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Life Science Business Department, Shimadzu Corporation
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives

Mass spectrometry imaging of gamma-aminobutyric acid and glutamic acid decarboxylase reactions at various stages of banana ripening

J Biosci Bioeng. 2024 Oct 30:S1389-1723(24)00283-4.

  • Shiho Ishimoto1
  • Eiichiro Fukusaki1,2,3
  • Shuichi Shimma1,2,3
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  3. 3 Institute for Open and Transdisciplinary Research Initiatives, Osaka University

Multimass Analysis of Adeno-Associated Virus Vectors by Orbitrap-Based Charge Detection Mass Spectrometry

Analytical Chemistry 2024 96 (42), 17037-17046

  • Ryoji Nakatsuka1,2,3
  • Yuki Yamaguchi1
  • Kiichi Hirohata1
  • Saki Shimojo1
  • Makoto Murakami1
  • Mark Allen Vergara Rocafort1
  • Yasuo Tsunaka1
  • Mitsuko Fukuhara1,4
  • Tetsuo Torisu1
  • Susumu Uchiyama1
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
  2. 2 Technology Research Laboratory, Shimadzu Corporation, 1 Nishinokyo-Kuwabaracho, Nakagyo-ku, Kyoto 604-8511, Japan
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
  4. 4 U-Medico Inc., 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Towards more realistic cultivated meat by rethinking bioengineering approaches

Trends in Biotechnology

  • Marie Piantino1
  • Quentin Muller1
  • Chika Nakadozono1,2,3,4
  • Asuka Yamada1,2,5
  • Michiya Matsusaki1,2
  1. 1 Consortium for Future Innovation by Cultured Meat, Osaka, Japan
  2. 2 Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan
  3. 3 Shimadzu Analytical Innovation Research Laboratories, Osaka University, Osaka, Japan
  4. 4 Shimadzu Corporation, Kyoto, Japan
  5. 5 Toppan Holdings Inc., Business Development Division, Technical Research Institute, Saitama, Japan

Novel mimetic tissue standards for precise quantitative mass spectrometry imaging of drug and neurotransmitter concentrations in rat brain tissues

Anal Bioanal Chem.

  • Kenichi Watanabe1
  • Sayo Takayama1
  • Toichiro Yamada1
  • Masayo Hashimoto1
  • Jun Tadano2
  • Tetsuya Nakagawa2
  • Takao Watanabe3
  • Eiichiro Fukusaki4,5,6
  • Izuru Miyawaki1
  • Shuichi Shimma4,5,6
  1. 1 Preclinical Research Unit, Sumitomo Pharma Co., Ltd
  2. 2 Research Planning & Coordination, Sumitomo Pharma Co., Ltd
  3. 3 Drug Research Division, Sumitomo Pharma Co., Ltd
  4. 4 Department of Biotechnology, Graduate School of Engineering, Osaka University
  5. 5 Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  6. 6 Osaka University Shimadzu Omics Innovation Research Laboratory, Osaka University.

REACH Project : For Strategic Development of Highly Skilled Human Resources through Academia-Industry Collaboration

Manufacturing & technology / 大阪大学生産技術研究会 編 76 (3), 62-66, 2024

  • Daisuke Hiramaru
  • Junko Iida
  • Hiroaki Nakanishi
  1. Osaka University Shimadzu Omics Innovation Research Laboratory, Osaka University

New insights into the characteristic flavor components of traditional sour beers such as Lambic and Flanders Red Ale beers

J Biosci Bioeng . 2024 Jul;138(1):54-62

  • Kyoya Onishi1
  • Masahiro Furuno1
  • Asuka Mori1
  • Eiichiro Fukusaki1,2,3
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, Osaka University
  3. 3 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University

Characteristics of kopyor coconut (Cocos nucifera L.) using sensory analysis and metabolomics-based approach

J Biosci Bioeng. 2024 Jul;138(1):44-53

  • Mercy Bientri Yunindanova1,2
  • Sastia Prama Putri1,3
  • Hengky Novarianto5
  • Eiichiro Fukusaki1,3,4
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Study Program of Agrotechnology, Faculty of Agriculture, Universitas Sebelas Maret
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives
  4. 4 Osaka University Shimadzu Omics Innovation Research Laboratories, International Center for Biotechnology
  5. 5 National Research and Innovation Agency (BRIN)

Multidisciplinary approach combining food metabolomics and epidemiology identifies meglutol as an important bioactive metabolite in tempe, an Indonesian fermented food

Food Chem . 2024 Jul 15:446:138744

  • Marvin N. Imana
  • Danielle E. Haslamb d
  • Liming Liange f
  • Kai Guog
  • Kaumudi Joshipurae g
  • Cynthia M. Pérezh
  • Clary Clishi
  • Katherine L. Tuckerj
  • JoAnn E. Mansonc
  • Shilpa N. Bhupathirajub d
  • Eiichiro Fukusakia k l
  • Jessica Lasky-Sub
  • Sastia P. Putria l
  1. a Department of Biotechnology, Graduate School of Engineering,
  2. b Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
  3. c Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
  4. d Department of Nutrition, Harvard T.H. Chan School of Public Health,
  5. e Department of Epidemiology, Harvard T.H. Chan School of Public Health
  6. f Department of Biostatistics, Harvard T.H. Chan School of Public Health
  7. g Center for Clinical Research and Health Promotion, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus
  8. h Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus
  9. i Broad Institute of Massachusetts Institute of Technology and Harvard,
  10. j Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell
  11. k Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  12. l Osaka University-Shimadzu Omics Innovation Research Laboratories, Osaka University

Metabolomic characterization of monoclonal antibody-producing Chinese hamster lung (CHL)-YN cells in glucose-controlled serum-free fed-batch operation

Biotechnology and Bioengineering

  • Puriwat Sukwattananipaat1
  • Hirotaka Kuroda1,2,3
  • Noriko Yamano-Adachi1,4,5
  • Takeshi Omasa1,4,5
  1. 1 Graduate School of Engineering, Osaka University
  2. 2 Shimadzu Corp.
  3. 3 Shimadzu Analytical Innovation Research Laboratories
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  5. 5 Manufacturing Technology Association of Biologics (MAB)

13C-metabolic flux analysis reveals metabolic rewiring in HL-60 neutrophil-like cells through differentiation and immune stimulation

Metab Eng Commun . 2024 May 27:18:e00239

  • Takeo Taniguchi1
  • Nobuyuki Okahashi1,2,3
  • Fumio Matsuda1,2,3
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Department of Biotechnology, Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University.
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University

New insights into the characteristic flavor components of traditional sour beers such as Lambic and Flanders Red Ale beers

J Biosci Bioeng. 2024 Apr 22:S1389-1723(24)00111-7

  • Kyoya Onishi1
  • Masahiro Furuno1
  • Asuka Mori1
  • Eiichiro Fukusaki1,2,3
  1. 1 Department of Biotechnology, Graduate School of Engineering, Osaka University
  2. 2 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiative, Osaka University
  3. 3 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University,

Identification and enzymatic properties of arginine decarboxylase from Aspergillus oryzae

Appl Environ Microbiol. 2024 Apr 16:e0029424

  • Yui Murakami1
  • Soichiro Ikuta2
  • Wakao Fukuda2
  • Naoki Akasaka1,3
  • Jun-Ichi Maruyama4,5
  • Shuichi Shinma6,7,8
  • Eiichiro Fukusaki6,7,8
  • Shinsuke Fujiwara1,2
  1. 1 Department of Biosciences, Graduate School of Science and Technology, Kwansei-Gakuin University
  2. 2 Department of Biosciences, School of Biological and Environmental Sciences
  3. 3 Laboratory for Circular Bioeconomy Development, Office of Society-Academia Collaboration for Innovation, Kyoto University
  4. 4 Department of Biotechnology, The University of Tokyo
  5. 5 Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
  6. 6 Department of Biotechnology, Graduate School of Engineering, Osaka University
  7. 7 Osaka University Shimadzu Analytical Innovation Laboratory, Osaka University
  8. 8 Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University.

Development of a Mass Spectrometry Imaging Method to Evaluate the Penetration of Moisturizing Components Coated on Surgical Gloves into Artificial Membranes

Mass Spectrom (Tokyo) . 2024;13(1):A0145

  • Erika Nagano1
  • Kazuki Odake1
  • Toru Akiyoshi2
  • Shuichi Shimma 1,3,4,5
  1. 1 Research and Development Department, Miruion Corporation
  2. 2 Marketing Department, Cardinal Health K.K.
  3. 3 Department of Biotechnology, Graduate School of Engineering, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  5. 5 Osaka University Shimadzu Omics Innovation Research Laboratory, Osaka University

Metabolome analysis of metabolic burden in Escherichia coli caused by overexpression of green fluorescent protein and delta-rhodopsin

J Biosci Bioeng. 2024 Mar;137(3):187-194.

  • Chinatsu Matsuyama1
  • Taisuke Seike1
  • Nobuyuki Okahashi1,2
  • Teppei Niide1
  • Kiyotaka Y. Hara3
  • Yoko Hirono-Hara4
  • Jun Ishii5
  • Hiroshi Shimizu1
  • Yoshihiro Toya1
  • Fumio Matsuda1,2
  1. 1 Graduate School of Information Science and Technology, Osaka University
  2. 2 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University
  3. 3 Department of Environmental and Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka
  4. 4 396Bio Inc.
  5. 5 Engineering Biology Research Center, Kobe University

Rice grain structural characteristics of sake rice cultivar Hakutsurunishiki for daiginjo-shu brewing

Biosci Biotechnol Biochem. 2024 Mar 22;88(4):445-452

  • Yoshihiro Tamada1,2
  • Takuya Asai1
  • Takafumi Kubodera1
  • Takahiro Akashi1
  • Eiichiro Fukusaki2,3,4
  • Shuichi Shimma2,3,4
  1. 1 Hakutsuru Sake Brewing Co., Ltd.
  2. 2 Department of Biotechnology, Graduate School of Engineering, Osaka University
  3. 3 Osaka University Shimadzu Omics Innovation Research Laboratory, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University

Multidisciplinary approach combining food metabolomics and epidemiology identifies meglutol as an important bioactive metabolite in tempe, an Indonesian fermented food

Food Chem. 2024 Feb 16:446:138744.

  • Marvin N. Imana 1
  • Danielle E. Haslamb d 1
  • Liming Liange f
  • Kai Guog
  • Kaumudi Joshipurae g
  • Cynthia M. Pérezh
  • Clary Clishi
  • Katherine L. Tuckerj
  • JoAnn E. Mansonc
  • Shilpa N. Bhupathirajub d 2
  • Eiichiro Fukusakia k l 2
  • Jessica Lasky-Sub 2
  • Sastia P. Putria l 2
  1. a Department of Biotechnology, Graduate School of Engineering, Osaka University,
  2. b Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
  3. c Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
  4. d Department of Nutrition, Harvard T.H. Chan School of Public Health
  5. e Department of Epidemiology, Harvard T.H. Chan School of Public Health
  6. f Department of Biostatistics, Harvard T.H. Chan School of Public Health,
  7. g Center for Clinical Research and Health Promotion, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus
  8. h Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus
  9. i Broad Institute of Massachusetts Institute of Technology and Harvard
  10. j Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell
  11. k Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  12. l Osaka University-Shimadzu Omics Innovation Research Laboratories, Osaka University
  13. 1 These authors contributed equally: Marvin N. Iman, Danielle E. Haslam.
  14. 2 Joint senior authors, contributed equally: Shilpa N. Bhupathiraju, Eiichiro Fukusaki, Jessica Lasky-Su, Sastia P. Putri.

A Bayesian approach for constituent estimation in nucleic acid mixture models

Front. Anal. Sci., 08 Jan 2024, 10.3389/frans.2023.1301602

  • Taichi Tomono1,2,3
  • Satoshi Hara1
  • Yusuke Nakai2
  • Kazuma Takahara2
  • Junko Iida3,4
  • Takashi Washio1
  1. 1 Department of Reasoning for Intelligence, The Institute of Scientific and Industrial Research, Osaka University, Ōsaka, Japan
  2. 2 AI Solution Unit, Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan
  3. 3 Shimadzu Analytical Innovation Research Laboratories, Osaka University, Ōsaka, Japan
  4. 4 Life Science Business Department, Analytical and Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

2023

Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study

J Chromatogr A 1708(2023) 464333.

  • Momoka　Hayashida1,2,3
  • Risa Suzuki3
  • Shinnosuke Horie2,3,4
  • Junichi Masuda3
  • Takao Yamaguchi1
  • Satoshi Obika1
  1. 1 Graduate School of Pharmaceutical Sciences, Osaka University
  2. 2 Shimadzu Analytical Innovation Research Laboratories
  3. 3 Shimadzu Corporation
  4. 4 Shimadzu Europa GmbH

Lipidome and metabolome analyses reveal metabolic alterations associated with MCF-7 apoptosis upon 4-hydroxytamoxifen treatment

Sci. Rep. (2023) 13:18549

  • Kazuki Nishimoto1
  • Nobuyuki Okahashi1,2,3
  • Masaharu Maruyama1
  • Yoshihiro Izumi4
  • Kohta Nakatani4
  • Yuki Ito2,5
  • Junko Iida2,5
  • Takeshi Bamba4
  • Fumio Matsuda1,2,3
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Department of Biotechnology, Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  4. 4 Division of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University
  5. 5 Analytical and Measuring Instruments Division, Shimadzu Corporation

Lipidome variation of industrial Saccharomyces cerevisiae strains analyzed by LC-QTOF/MS-based untargeted lipidomics

J Biosci Bioeng, 135(2) 102-108

  • Shuka Komori1
  • Nobuyuki Okahashi1 2 3
  • Junko Iida2 4
  • Fumio Matsuda1 2 3
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  4. 4 Analytical and Measuring Instruments Division, Shimadzu Corporation

2022

Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform

Metabolites 2022, 12(7), 646

  • Nobuyuki Okahashi1 2 3
  • Yuki Yamada1
  • Junko Iida2 4
  • Fumio Matsuda1 2 3
  1. 1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
  2. 2 Department of Biotechnology, Osaka University Shimadzu Analytical Innovation Research Laboratory, Graduate School of Engineering, Osaka University
  3. 3 Industrial Biotechnology Initiative Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
  4. 4 Analytical and Measuring Instruments Division, Shimadzu Corporation

Automated Recommendation of Research Keywords from PubMed That Suggest the Molecular Mechanism Associated with Biomarker Metabolites

Metabolites

  • Shinji Kanazawa 1,2,3
  • Satoshi Shimizu 1
  • Shigeki Kajihara 1
  • Norio Mukai 1
  • Junko Iida 1,2
  • Fumio Matsuda 3,4
  1. 1 Shimadzu Corporation
  2. 2 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University
  3. 3 Graduate School of Information Science and Technology, Osaka University
  4. 4 Institute for Open and Transdisciplinary Research Initiatives, Osaka University

2021

Evaluation of change in metabolome caused by comprehensive diabetes treatment: A prospective observational study of diabetes inpatients with gas chromatography/mass spectrometry-based non-target metabolomic analysis

journal of diabetes investigation

  • Naohiro Taya 1
  • Naoto Katakami 1,2
  • Kazuo Omori 1
  • Shoya Arakawa 3
  • Shigero Hosoe 1
  • Hirotaka Watanabe 1
  • Mitsuyoshi Takahara 1,4
  • Kazuyuki Miyashita 1
  • Hitoshi Nishizawa 1
  • Taka-Aki Matsuoka 1
  • Masahiro Furuno 3
  • Takeshi Bamba 5
  • Junko Iida 6,7
  • Eiichiro Fukusaki 3
  • Iichiro Shimomura 1
  1. 1 Department of Metabolic Medicine, Osaka University Graduate School of Medicine
  2. 2 Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine
  3. 3 Laboratory of Bioresource Engineering, Department of Biotechnology, Graduate School of Engineering, Osaka University
  4. 4 Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University
  5. 5 Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
  6. 6 Shimadzu Corporation
  7. 7 Osaka University Shimadzu Omics Innovation Research Laboratories, Graduate School of Engineering, Osaka University

Fake metabolomics chromatogram generation for facilitating deep learning of peak-picking neural networks

Journal of Bioscience and Bioengineering

  • Shinji Kanazawa 1,2,3
  • Akira Noda 1
  • Arisa Ito 2
  • Kyoko Hashimoto 2
  • Akihiro Kunisawa 1
  • Tsuyoshi Nakanishi 1
  • Shigeki Kajihara 1
  • Norio Mukai 1
  • Junko Iida 1,2
  • Eiichiro Fukusaki 4
  • Fumio Matsuda 3
MORE
  • 1 Shimadzu Corporation
  • 2 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University
  • 3 Graduate School of Information Science and Technology, Osaka University
  • 4 Graduate School of Engineering, Osaka University

2019

Fragmentation of Dicarboxylic and Tricarboxylic Acids in the Krebs Cycle Using GC-EI-MS and GC-EI-MS/MS

Mass Spectrometry

  • Nobuyuki Okahashi 1
  • Shuichi Kawana 2
  • Junko Iida 2,3
  • Hiroshi Shimizu 1
  • Fumio Matsuda 1
  1. 1 Graduate School of Information Science and Technology, Osaka University
  2. 2 Shimadzu Corporation
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

2018

Free D-amino acids produced by commensal bacteria in the colonic lumen

Scientific Reports (2018), DOI:10.1038/s41598-018-36244-z

  • Mitsuharu Matsumoto 1
  • Akihiro Kunisawa 2,3
  • Takanari Hattori 2,3
  • Shuichi Kawana 2
  • Yusuke Kitada 1
  • Hazuki Tamada 1
  • Shinichi Kawano 2,3
  • Yoshihiro Hayakawa 2
  • Junko Iida 2,3
  • Eiichiro Fukusaki 3,4
  1. 1 Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd
  2. 2 Shimadzu Corporation
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  4. 4 Graduate School of Information Science and Technology, Osaka University

Sugar phosphate analysis with baseline separation and soft ionization by gas chromatography-negative chemical ionization-mass spectrometry improves flux estimation of bidirectional reactions in cancer cells

Metabolic Engineering (2018)

  • Nobuyuki Okahashi 1
  • Kousuke Maeda 1
  • Shuichi Kawana 2
  • Junko Iida 2,3
  • Hiroshi Shimizu 1
  • Fumio Matsuda 1
  1. 1 Graduate School of Information Science and Technology, Osaka University
  2. 2 Shimadzu Corporation
  3. 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

FK960 binding proteins, quinone oxidoreductase2 and pyridoxal kinase were identified by LC-MS/MS for drug discovery of Alzheimer's treatment

Trends in Research (2018), DOI:10.15761/TR.1000113

  • Zenzaburo Tozuka 1,2,3
  • Akihiro Kunisawa 2
  • Fumiyuki Shirai 3,4
  • Yoshinori Ishii 3,4
  1. 1 Graduate School of Pharmaceutical Science, Osaka University
  2. 2 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  3. 3 Fujisawa Pharmaceutical Co., Ltd.
  4. 4 Astellas Pharma Inc.

Multi omics by LC-MS/MS to search small molecule ligands of nuclear receptors to control transcription of pharmaceutical active proteins for drug discovery

Trends in Research (2018), DOI: 10.15761/TR.1000111

  • Zenzaburo Tozuka, Akihiro Kunisawa
  1. Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

2016

GC-MS/MS survey of collision-induced dissociation of tert-butyldimethylsilyl-derivatized amino acids and its application to 13C-metabolic flux analysis of Escherichia coli central metabolism

Analytical and Bioanalytical Chemistry, June, 2016, in press.

  • Nobuyuki Okahashi 1
  • Shuichi Kawana 2
  • Junko Iida 2,3
  • Hiroshi Shimizu 1
  • Fumio Matsuda 1
  1. 1 Graduate School of Information Science and Technology, Osaka University
  2. 2 Shimadzu Co.
  3. 3 Graduate School of Engineering, Osaka University
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