A paper describing a new method to acquire sugar chain structural information, which was difficult previously, has been published in Analytical Chemistry, one of the world’s most authoritative journals in the field of analytical chemistry, including mass spectrometry.
This method extends the AQ labeling method for measuring sugar chain structure information that was developed in this project. The paper introduces the example of the sugar chain analysis of HER2, a characteristic glycoprotein in breast cancer, but the method can be widely applied to other organism-related sugar chains.
Takashi Nishikaze, Kaoru Kaneshiro, Shin-ichirou Kawabata, Koichi Tanaka
“Structural Analysis of N-Glycans by the Glycan-Labeling Method Using 3-Aminoquinoline-Based Liquid Matrix in Negative-Ion MALDIMS”, Analytical Chemistry., 2012, Vol. 84 No.21, pp9453-9461
Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
Presentation materials (Link to overview of the paper published in Analytical Chemistry)
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Newly-arrived related information:
Aug. 22, 2012: [Materials Provided] Paper on high sensitivity detection of differences in breast cancer related proteins published.
Jun. 20, 2011: [Materials Provided] First paper from Koichi Tanaka Laboratory of Advanced Science and Technology published in Analytical Chemistry.
