Aug. 22, 2012: [Materials Provided] Paper on high sensitivity detection of differences in breast cancer related proteins published.

A paper has been published in “Analytical Chemistry,” one of the most globally prominent academic journals in the field of analytical chemistry, including mass spectrometry. This paper discusses the high sensitivity detection of differences in sugar chains of HER2, a glycoprotein specific to some forms of breast cancer. In this method, high sensitivity levels are easily obtained by mixing sugar chains with liquid matrix 3-AQ/CHCA, an ionization adjuvant, and then applying heat. This method can be used to distinguish differences in the sugar chain modification patterns not only for HER2 but also for a variety of glycoproteins and sugars.

style=”padding-left:1em”>Kaoru Kaneshiro 1, Makoto Watanabe 1, Kazuya Terasawa 2, Hiromasa Uchimura 2,
Yuko Fukuyama 1, Shinichi Iwamoto 1, Taka-Aki Sato 1, Kazuharu Shimizu 2, Gozoh Tsujimoto 2, Koichi Tanaka 1
“Rapid Quantitative Profiling of N-Glycan by the Glycan-Labeling Method Using 3-Aminoquinoline/α-Cyano-4-hydroxycinnamic Acid”, Analytical Chemistry, 2012, Vol. 84 No.14, pp7146-7151
1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
2 Graduate School of Pharmaceutical Sciences, Kyoto University

Presentation materials (Link to overview of the paper published in Analytical Chemistry)


Newly-arrived related information:
Jun. 20, 2011: [Materials Provided] First paper from Koichi Tanaka Laboratory of Advanced Science and Technology published in Analytical Chemistry.