A paper on the results of research into high sensitivity for sugar chain has been published in “Analytical Chemistry,” one of the most globally prominent academic journals in the field of analytical chemistry, including mass spectrometry. The results describe how combining a suitable additive (mineral salt) with a previously developed ionization adjuvant (liquid matrix G3CA) enables measurement of neutral sugar chains with at least a 100 fold improvement in sensitivity over conventional methods.
Takashi Nishikaze1, Yuko Fukuyama1, Shin-ichirou Kawabata1, Koichi Tanaka1
“Sensitive Analyses of Neutral N-Glycans using Anion-Doped Liquid Matrix G3CA by Negative-Ion Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry”, Analytical Chemistry., 2012, Vol. 84 No.14, pp6097-6103
1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
Presentation materials (Link to overview of the paper published in Analytical Chemistry)
