The results of 3 studies representing a portion of the research achievements for 2011 from the Koichi Tanaka Laboratory of Advanced Science and Technology were presented at the 60th ASMS Conference on Mass Spectrometry (May 20 to 24, 2012, in Vancouver).
The majority of the achievements for 2011 is scheduled to be summarized and presented at the IMSC2012 KYOTO International Mass Spectrometry Conference (September 16 to 20, 2012, in Kyoto).
ASMS website: http://www.asms.org/
| 1. [TP200] | Takashi Nishikaze1, Yuko Fukuyama1, Shin-ichirou Kawabata1, Koichi Tanaka1 1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation |
| Sensitive Analysis of Neutral N-Glycan using Anion Doped Liquid Matrix by Negative-Ion Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry → Describes how it is possible to significantly increase negative ion MS and MS/MS sensitivity (maximizing the detection limits to 100 amol) for neutral sugar molecules by adding negative ions (such as BF4-, NO3-) to a suitable liquid matrix (such as G3CA). Presentation materials（371KB） |
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| 2. [ThP286] | Yoshihiro Yamada1, Yuko Fukuyama1, Natsumi Funakoshi2, Hidenori Takahashi1, Masaki Murase1, Shigeki Kajihara1, Koichi Tanaka1 1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation |
| Data dependent acquisition with peptide identification probability estimation during comprehensive analysis → Describes an automatic analysis method that can maximize expectation values for peptides identified based on estimated values for peptide identification probabilities, utilizing repeated analysis, a feature of MALDI-MS. In addition to precursor selection, it is possible to optimize cumulated numbers in MS2 analyses. Presentation materials（608KB） |
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| 3. [ThP665] | Yuko Fukuyama1, Ritsuko Tanimura1, Kazuki Maeda2, Makoto Watanabe1, Shin-Ichirou Kawabata1, Shinichi Iwamoto1, Shunsuke Izumi2, Koichi Tanaka1 1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation, 2 Hiroshima University |
| An Alkylated Dihydroxybenzoic Acid Derivative as a Novel MALDI Matrix Additive for Sensitive Detection of Hydrophobic Peptides → Describes how up to 100 fold improved sensitivity for hydrophobic peptides was achieved by adding ADHB (replacing the DHBA OH group with the hydrophobic alkyl group) to conventionally used solid Matrix CHCA. Presentation materials（530KB） |
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