　The second paper from the Koichi Tanaka Laboratory of Advanced Science and Technology was published in “Rapid Communications in Mass Spectrometry,” a prominent academic journal that posts breaking news regarding the latest technologies in the field of mass spectrometry. By “planting” an antibody on the very fine surface of an immunobead, beta amyloid in the solution was recovered. Then, high-sensitivity detection at the level of 1 fmol was achieved using direct measurement by MALDI-MS.
Takashi Shimada1,2, Atsuhiko Toyama1, Chikage Aoki1, Yutaka Aoki1, Koichi Tanaka2,3, Taka-Aki Sato1,2
“Direct antigen detection from immunoprecipitated beads using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; a new method for immunobeads-mass spectrometry (iMS)”, Rapid Commun. Mass Spectrom. 2011, 25, pp3521-3526
1 Life Science Research Center, Shimadzu Corporation
2 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation
3 Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation
